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LRRK2-G2019S Synergizes with Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation that Precede Nigrostriatal Degeneration

View ORCID ProfileCarmela Giachino, View ORCID ProfileCataldo Tirolo, View ORCID ProfileSalvatore Caniglia, View ORCID ProfileMaria F. Serapide, View ORCID ProfileFrancesca L’Episcopo, View ORCID ProfileFederico Bertoli, Claudio Giuliano, Marika Mearelli, View ORCID ProfileMeike Jakobi, View ORCID ProfileNicole Schneiderhan-Marra, View ORCID ProfileMichela Deleidi, View ORCID ProfileBianca Marchetti
doi: https://doi.org/10.1101/2022.09.01.505977
Carmela Giachino
1OASI-Research Institute-IRCCS, Neuropharmacology Laboratory, Troina-EN-Italy
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  • ORCID record for Carmela Giachino
Cataldo Tirolo
1OASI-Research Institute-IRCCS, Neuropharmacology Laboratory, Troina-EN-Italy
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  • ORCID record for Cataldo Tirolo
Salvatore Caniglia
1OASI-Research Institute-IRCCS, Neuropharmacology Laboratory, Troina-EN-Italy
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  • ORCID record for Salvatore Caniglia
Maria F. Serapide
2Biomedical and Biotechnological Sciences, Pharmacology Section, University of Catania-Italy
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  • ORCID record for Maria F. Serapide
Francesca L’Episcopo
1OASI-Research Institute-IRCCS, Neuropharmacology Laboratory, Troina-EN-Italy
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  • ORCID record for Francesca L’Episcopo
Federico Bertoli
3Mitochondria and Inflammation in Neurodegenerative Diseases, DZNE, Tübingen-Germany
4Hertie Institute for Clinical Brain Research, University of Tübingen
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Claudio Giuliano
3Mitochondria and Inflammation in Neurodegenerative Diseases, DZNE, Tübingen-Germany
4Hertie Institute for Clinical Brain Research, University of Tübingen
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Marika Mearelli
3Mitochondria and Inflammation in Neurodegenerative Diseases, DZNE, Tübingen-Germany
4Hertie Institute for Clinical Brain Research, University of Tübingen
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Meike Jakobi
5NMI Natural and Medical Sciences Institute, University of Tübingen, Reutlingen, Germany
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  • ORCID record for Meike Jakobi
Nicole Schneiderhan-Marra
5NMI Natural and Medical Sciences Institute, University of Tübingen, Reutlingen, Germany
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  • ORCID record for Nicole Schneiderhan-Marra
Michela Deleidi
3Mitochondria and Inflammation in Neurodegenerative Diseases, DZNE, Tübingen-Germany
4Hertie Institute for Clinical Brain Research, University of Tübingen
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  • For correspondence: biancamarchetti@libero.it michela.deleidi@dzne.de
Bianca Marchetti
1OASI-Research Institute-IRCCS, Neuropharmacology Laboratory, Troina-EN-Italy
2Biomedical and Biotechnological Sciences, Pharmacology Section, University of Catania-Italy
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  • For correspondence: biancamarchetti@libero.it michela.deleidi@dzne.de
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Article Information

doi 
https://doi.org/10.1101/2022.09.01.505977
History 
  • September 3, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Carmela Giachino1,
  2. Cataldo Tirolo1,
  3. Salvatore Caniglia1,
  4. Maria F. Serapide2,
  5. Francesca L’Episcopo1,
  6. Federico Bertoli3,4,
  7. Claudio Giuliano3,4,
  8. Marika Mearelli3,4,
  9. Meike Jakobi5,
  10. Nicole Schneiderhan-Marra5,
  11. Michela Deleidi3,4,*,# and
  12. Bianca Marchetti1,2,*,#
  1. 1OASI-Research Institute-IRCCS, Neuropharmacology Laboratory, Troina-EN-Italy
  2. 2Biomedical and Biotechnological Sciences, Pharmacology Section, University of Catania-Italy
  3. 3Mitochondria and Inflammation in Neurodegenerative Diseases, DZNE, Tübingen-Germany
  4. 4Hertie Institute for Clinical Brain Research, University of Tübingen
  5. 5NMI Natural and Medical Sciences Institute, University of Tübingen, Reutlingen, Germany
  1. ↵*Corresponding authors: biancamarchetti{at}libero.it; michela.deleidi{at}dzne.de
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Posted September 03, 2022.
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LRRK2-G2019S Synergizes with Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation that Precede Nigrostriatal Degeneration
Carmela Giachino, Cataldo Tirolo, Salvatore Caniglia, Maria F. Serapide, Francesca L’Episcopo, Federico Bertoli, Claudio Giuliano, Marika Mearelli, Meike Jakobi, Nicole Schneiderhan-Marra, Michela Deleidi, Bianca Marchetti
bioRxiv 2022.09.01.505977; doi: https://doi.org/10.1101/2022.09.01.505977
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LRRK2-G2019S Synergizes with Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation that Precede Nigrostriatal Degeneration
Carmela Giachino, Cataldo Tirolo, Salvatore Caniglia, Maria F. Serapide, Francesca L’Episcopo, Federico Bertoli, Claudio Giuliano, Marika Mearelli, Meike Jakobi, Nicole Schneiderhan-Marra, Michela Deleidi, Bianca Marchetti
bioRxiv 2022.09.01.505977; doi: https://doi.org/10.1101/2022.09.01.505977

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