Co-substrate pools can constrain and regulate pathway fluxes in cell metabolism

Robert West; Hadrien Delattre; Elad Noor; Elisenda Feliu; Orkun S Soyer

doi:10.1101/2022.09.05.506656

Article Information

doi

https://doi.org/10.1101/2022.09.05.506656

History

September 6, 2022.

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.

Author Information

Robert West1,
Hadrien Delattre1,
Elad Noor2,
Elisenda Feliu3,* and
Orkun S Soyer1,*

¹School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK
²Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel
³Department of Mathematics, University of Copenhagen, Copenhagen, Denmark

↵*Corresponding Authors:
Orkun S Soyer, University of Warwick, Coventry, CV4 7AL, UK, + 44 (0)24 7657 4251, o.soyer{at}warwick.ac.uk. Elisenda Feliu, University of Copenhagen, Copenhagen, Universitetsparken 5, 2100, Denmark, +45 (0)35320794, efeliu{at}math.ku.dk.

Authors contributions: HD and OSS have devised the study. RW, EN, HD, OSS, and EF performed analyses and simulations, interpreted the results, and wrote the manuscript.