Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis

Samantha Y. Quintanilla, Neda Habibi Arejan, Parthvi B. Patel, View ORCID ProfileCara C. Boutte
doi: https://doi.org/10.1101/2022.09.08.507195
Samantha Y. Quintanilla
1Department of Biology, University of Texas Arlington, Arlington, TX
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Neda Habibi Arejan
1Department of Biology, University of Texas Arlington, Arlington, TX
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Parthvi B. Patel
1Department of Biology, University of Texas Arlington, Arlington, TX
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cara C. Boutte
1Department of Biology, University of Texas Arlington, Arlington, TX
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Cara C. Boutte
  • For correspondence: cara.boutte@uta.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Mycobacteria expand their cell walls at the cell poles in a manner that is not well described at the molecular level. In this study, we identify a new factor, PlrA, involved in restricting peptidoglycan metabolism to the cell poles in Mycobacterium smegmatis. We show that PlrA localizes to the pole tips, and we identify its essential domain. We show that depletion of plrA pheno-copies depletion of polar growth factor Wag31, and that PlrA is involved in regulating polar peptidoglycan metabolism and the structure of the Wag31 polar foci.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted September 08, 2022.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis
Samantha Y. Quintanilla, Neda Habibi Arejan, Parthvi B. Patel, Cara C. Boutte
bioRxiv 2022.09.08.507195; doi: https://doi.org/10.1101/2022.09.08.507195
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis
Samantha Y. Quintanilla, Neda Habibi Arejan, Parthvi B. Patel, Cara C. Boutte
bioRxiv 2022.09.08.507195; doi: https://doi.org/10.1101/2022.09.08.507195

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Microbiology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4105)
  • Biochemistry (8808)
  • Bioengineering (6509)
  • Bioinformatics (23446)
  • Biophysics (11784)
  • Cancer Biology (9198)
  • Cell Biology (13314)
  • Clinical Trials (138)
  • Developmental Biology (7430)
  • Ecology (11402)
  • Epidemiology (2066)
  • Evolutionary Biology (15142)
  • Genetics (10430)
  • Genomics (14036)
  • Immunology (9167)
  • Microbiology (22142)
  • Molecular Biology (8802)
  • Neuroscience (47534)
  • Paleontology (350)
  • Pathology (1427)
  • Pharmacology and Toxicology (2489)
  • Physiology (3729)
  • Plant Biology (8076)
  • Scientific Communication and Education (1437)
  • Synthetic Biology (2220)
  • Systems Biology (6036)
  • Zoology (1252)