Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Synchronous multi-segmental activity between metachronal waves controls locomotion speed in Drosophila larvae

Yingtao Liu, Eri Hasegawa, Akinao Nose, Maarten F. Zwart, View ORCID ProfileHiroshi Kohsaka
doi: https://doi.org/10.1101/2022.09.08.507222
Yingtao Liu
aDepartment of Physics, Graduate School of Science, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 133-0033 Tokyo, Japan
bDepartment of Complexity Science and Engineering, Graduate School of Frontier Science, the University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, 277-8561 Chiba, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eri Hasegawa
bDepartment of Complexity Science and Engineering, Graduate School of Frontier Science, the University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, 277-8561 Chiba, Japan
eFrontier Science and Social Co-creation Initiative, Kanazawa University, Kakuma, Kanazawa, 920-1192, Ishikawa, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Akinao Nose
aDepartment of Physics, Graduate School of Science, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 133-0033 Tokyo, Japan
bDepartment of Complexity Science and Engineering, Graduate School of Frontier Science, the University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, 277-8561 Chiba, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maarten F. Zwart
cSchool of Psychology and Neuroscience, Centre of Biophotonics, University of St Andrews, St Andrews KY16 9JP, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: mfz@st-andrews.ac.uk kohsaka@edu.k.u-tokyo.ac.jp
Hiroshi Kohsaka
bDepartment of Complexity Science and Engineering, Graduate School of Frontier Science, the University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, 277-8561 Chiba, Japan
dGraduate School of Informatics and Engineering, the University of Electro-Communications, 1-5-1, Chofugaoka, Chofu-shi, 182-8585 Tokyo, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Hiroshi Kohsaka
  • For correspondence: mfz@st-andrews.ac.uk kohsaka@edu.k.u-tokyo.ac.jp
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

The ability to adjust the speed of locomotion is essential for survival. In limbed animals, the frequency of locomotion is modulated primarily by changing the duration of the stance phase. The underlying neural mechanisms of this selective modulation remain an open question. Here, we report a neural circuit controlling a similarly selective adjustment of locomotion frequency in Drosophila larvae. Drosophila larvae crawl using peristaltic waves of muscle contractions. We find that larvae adjust the frequency of locomotion mostly by varying the time between consecutive contraction waves, reminiscent of limbed locomotion. A specific set of muscles, the lateral transverse (LT) muscles, co-contract in all segments during this phase, the duration of which sets the duration of the interwave phase. We identify two types of GABAergic interneurons in the LT neural network, premotor neuron A26f and its presynaptic partner A31c, which exhibit segmentally synchronized activity and control locomotor frequency by setting the amplitude and duration of LT muscle contractions. Altogether, our results reveal an inhibitory central circuit that sets the frequency of locomotion by controlling the duration of the period in between peristaltic waves. Further analysis of the descending inputs onto this circuit will help understand the higher control of this selective modulation.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Back to top
PreviousNext
Posted September 10, 2022.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Synchronous multi-segmental activity between metachronal waves controls locomotion speed in Drosophila larvae
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Synchronous multi-segmental activity between metachronal waves controls locomotion speed in Drosophila larvae
Yingtao Liu, Eri Hasegawa, Akinao Nose, Maarten F. Zwart, Hiroshi Kohsaka
bioRxiv 2022.09.08.507222; doi: https://doi.org/10.1101/2022.09.08.507222
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Synchronous multi-segmental activity between metachronal waves controls locomotion speed in Drosophila larvae
Yingtao Liu, Eri Hasegawa, Akinao Nose, Maarten F. Zwart, Hiroshi Kohsaka
bioRxiv 2022.09.08.507222; doi: https://doi.org/10.1101/2022.09.08.507222

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4087)
  • Biochemistry (8766)
  • Bioengineering (6480)
  • Bioinformatics (23346)
  • Biophysics (11751)
  • Cancer Biology (9149)
  • Cell Biology (13255)
  • Clinical Trials (138)
  • Developmental Biology (7417)
  • Ecology (11369)
  • Epidemiology (2066)
  • Evolutionary Biology (15088)
  • Genetics (10402)
  • Genomics (14011)
  • Immunology (9122)
  • Microbiology (22050)
  • Molecular Biology (8780)
  • Neuroscience (47373)
  • Paleontology (350)
  • Pathology (1420)
  • Pharmacology and Toxicology (2482)
  • Physiology (3704)
  • Plant Biology (8050)
  • Scientific Communication and Education (1431)
  • Synthetic Biology (2209)
  • Systems Biology (6016)
  • Zoology (1250)