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Tethered agonist activated ADGRF1 structure reveals molecular preference for Gαq signalling

Daniel T. D. Jones, Andrew N. Dates, Shaun D. Rawson, Maggie M. Burruss, Colin H. Lipper, Stephen C. Blacklow
doi: https://doi.org/10.1101/2022.09.09.507336
Daniel T. D. Jones
1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA
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  • For correspondence: stephen_blacklow@hms.harvard.edu daniel_jones@hms.harvard.edu
Andrew N. Dates
1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA
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Shaun D. Rawson
1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA
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Maggie M. Burruss
1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA
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Colin H. Lipper
1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA
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Stephen C. Blacklow
1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA
2Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA
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  • For correspondence: stephen_blacklow@hms.harvard.edu daniel_jones@hms.harvard.edu
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Article Information

doi 
https://doi.org/10.1101/2022.09.09.507336
History 
  • September 10, 2022.

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  • You are currently viewing Version 1 of this article (September 10, 2022 - 00:20).
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.

Author Information

  1. Daniel T. D. Jones1,#,
  2. Andrew N. Dates1,
  3. Shaun D. Rawson1,
  4. Maggie M. Burruss1,
  5. Colin H. Lipper1 and
  6. Stephen C. Blacklow1,2,*,#
  1. 1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA
  2. 2Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA
  1. ↵#Correspondence: stephen_blacklow{at}hms.harvard.edu and daniel_jones{at}hms.harvard.edu.
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Posted September 10, 2022.
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Tethered agonist activated ADGRF1 structure reveals molecular preference for Gαq signalling
Daniel T. D. Jones, Andrew N. Dates, Shaun D. Rawson, Maggie M. Burruss, Colin H. Lipper, Stephen C. Blacklow
bioRxiv 2022.09.09.507336; doi: https://doi.org/10.1101/2022.09.09.507336
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Tethered agonist activated ADGRF1 structure reveals molecular preference for Gαq signalling
Daniel T. D. Jones, Andrew N. Dates, Shaun D. Rawson, Maggie M. Burruss, Colin H. Lipper, Stephen C. Blacklow
bioRxiv 2022.09.09.507336; doi: https://doi.org/10.1101/2022.09.09.507336

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