Tethered agonist activated ADGRF1 structure reveals molecular preference for Gαq signalling

Daniel T. D. Jones; Andrew N. Dates; Shaun D. Rawson; Maggie M. Burruss; Colin H. Lipper; Stephen C. Blacklow

doi:10.1101/2022.09.09.507336

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Tethered agonist activated ADGRF1 structure reveals molecular preference for Gα_q signalling

Daniel T. D. Jones, Andrew N. Dates, Shaun D. Rawson, Maggie M. Burruss, Colin H. Lipper, Stephen C. Blacklow

doi: https://doi.org/10.1101/2022.09.09.507336

Daniel T. D. Jones

1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA

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For correspondence: stephen_blacklow@hms.harvard.edu daniel_jones@hms.harvard.edu

Andrew N. Dates

1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA

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Shaun D. Rawson

1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA

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Maggie M. Burruss

1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA

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Colin H. Lipper

1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA

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Stephen C. Blacklow

1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA

2Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA

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For correspondence: stephen_blacklow@hms.harvard.edu daniel_jones@hms.harvard.edu

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Tethered agonist activated ADGRF1 structure reveals molecular preference for Gα_q signalling

Daniel T. D. Jones, Andrew N. Dates, Shaun D. Rawson, Maggie M. Burruss, Colin H. Lipper, Stephen C. Blacklow

bioRxiv 2022.09.09.507336; doi: https://doi.org/10.1101/2022.09.09.507336

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Tethered agonist activated ADGRF1 structure reveals molecular preference for Gα_q signalling

Daniel T. D. Jones, Andrew N. Dates, Shaun D. Rawson, Maggie M. Burruss, Colin H. Lipper, Stephen C. Blacklow

bioRxiv 2022.09.09.507336; doi: https://doi.org/10.1101/2022.09.09.507336

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