AlphaFold2-based fusion design deciphers crucial role of the E3 UFL1 N-terminal helix in E2 UFC1 binding and ufmylation

Sayanika Banerjee; Julia K Varga; Manoj Kumar; Guy Zoltsman; Michail N Isupov; Rina Rosenzweig; Ora Schueler-Furman; Reuven Wiener

doi:10.1101/2022.09.15.508077

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AlphaFold2-based fusion design deciphers crucial role of the E3 UFL1 N-terminal helix in E2 UFC1 binding and ufmylation

Sayanika Banerjee, View ORCID ProfileJulia K Varga, Manoj Kumar, Guy Zoltsman, Michail N Isupov, Rina Rosenzweig, View ORCID ProfileOra Schueler-Furman, View ORCID ProfileReuven Wiener

doi: https://doi.org/10.1101/2022.09.15.508077

Sayanika Banerjee

1Department of Biochemistry and Molecular Biology, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel

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Julia K Varga

2Department of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel

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ORCID record for Julia K Varga

Manoj Kumar

1Department of Biochemistry and Molecular Biology, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel

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Guy Zoltsman

3Department of Chemical and Structural Biology, Weizmann Institute of Sciences, Rehovot, Israel

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Michail N Isupov

4The Henry Wellcome Building for Biocatalysis, Biosciences, University of Exeter, Stocker Road, Exeter, EX4 4QD, United Kingdom

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Rina Rosenzweig

3Department of Chemical and Structural Biology, Weizmann Institute of Sciences, Rehovot, Israel

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Ora Schueler-Furman

2Department of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel

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ORCID record for Ora Schueler-Furman
For correspondence: ora.furman-schueler@mail.huji.ac.il reuvenw@ekmd.huji.ac.il

Reuven Wiener

1Department of Biochemistry and Molecular Biology, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel

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ORCID record for Reuven Wiener
For correspondence: ora.furman-schueler@mail.huji.ac.il reuvenw@ekmd.huji.ac.il

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Posted November 22, 2022.

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AlphaFold2-based fusion design deciphers crucial role of the E3 UFL1 N-terminal helix in E2 UFC1 binding and ufmylation

Sayanika Banerjee, Julia K Varga, Manoj Kumar, Guy Zoltsman, Michail N Isupov, Rina Rosenzweig, Ora Schueler-Furman, Reuven Wiener

bioRxiv 2022.09.15.508077; doi: https://doi.org/10.1101/2022.09.15.508077

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AlphaFold2-based fusion design deciphers crucial role of the E3 UFL1 N-terminal helix in E2 UFC1 binding and ufmylation

Sayanika Banerjee, Julia K Varga, Manoj Kumar, Guy Zoltsman, Michail N Isupov, Rina Rosenzweig, Ora Schueler-Furman, Reuven Wiener

bioRxiv 2022.09.15.508077; doi: https://doi.org/10.1101/2022.09.15.508077

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