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The genome sequence of the Lumpy Skin Disease virus from the outbreak in India suggests a distinct lineage of the virus

Lenin Bhatt, Rahul C. Bhoyar, View ORCID ProfileBani Jolly, Ravi Israni, Harie Vignesh, Vinod Scaria, Sridhar Sivasubbu
doi: https://doi.org/10.1101/2022.09.15.508131
Lenin Bhatt
1State Disease Diagnostic Centre, Department of Animal Husbandry, Jaipur 302001, Rajasthan
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Rahul C. Bhoyar
2CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110025, INDIA
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Bani Jolly
2CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110025, INDIA
3Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Campus, Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh 201002, INDIA
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Ravi Israni
1State Disease Diagnostic Centre, Department of Animal Husbandry, Jaipur 302001, Rajasthan
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Harie Vignesh
2CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110025, INDIA
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Vinod Scaria
2CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110025, INDIA
3Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Campus, Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh 201002, INDIA
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  • For correspondence: vinods@igib.in sridhar@igib.in s.sivasubbu@igib.res.in
Sridhar Sivasubbu
2CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110025, INDIA
3Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Campus, Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh 201002, INDIA
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  • For correspondence: vinods@igib.in sridhar@igib.in s.sivasubbu@igib.res.in
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ABSTRACT

Although previously confined to regions within Africa, Lumpy Skin Disease Virus (LSDV) infections have caused significantly large outbreaks in several regions of the world in very recent years. In 2019, an outbreak of the disease was reported from India with low rates of morbidity and no reported mortality. However, in 2022, an ongoing outbreak of LSDV spanning over 7 states in India resulted in a reported mortality of over 80,000 cattle over a short period of three months. Here, we report complete genome sequences of 6 viral isolates of LSDV collected from affected cattle during an ongoing outbreak of the disease in Rajasthan, India. Analysis of the viral sequences suggests the genomes from the 2022 outbreak harbour a large number of genetic variations compared to the reference genome and form a distinct lineage. This report also highlights the importance of genome sequencing and surveillance of transboundary infectious agents and genomic characterisation of outbreaks.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 16, 2022.
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The genome sequence of the Lumpy Skin Disease virus from the outbreak in India suggests a distinct lineage of the virus
Lenin Bhatt, Rahul C. Bhoyar, Bani Jolly, Ravi Israni, Harie Vignesh, Vinod Scaria, Sridhar Sivasubbu
bioRxiv 2022.09.15.508131; doi: https://doi.org/10.1101/2022.09.15.508131
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The genome sequence of the Lumpy Skin Disease virus from the outbreak in India suggests a distinct lineage of the virus
Lenin Bhatt, Rahul C. Bhoyar, Bani Jolly, Ravi Israni, Harie Vignesh, Vinod Scaria, Sridhar Sivasubbu
bioRxiv 2022.09.15.508131; doi: https://doi.org/10.1101/2022.09.15.508131

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