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Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies

Daniel J. Sheward, Changil Kim, Julian Fischbach, Sandra Muschiol, Roy A. Ehling, Niklas K. Björkström, Gunilla B. Karlsson Hedestam, Sai T. Reddy, Jan Albert, Thomas P. Peacock, Ben Murrell
doi: https://doi.org/10.1101/2022.09.16.508299
Daniel J. Sheward
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
2Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
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Changil Kim
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
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Julian Fischbach
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
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Sandra Muschiol
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
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Roy A. Ehling
3Department of Biosystems Science and Engineering, ETH Zürich
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Niklas K. Björkström
4Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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Gunilla B. Karlsson Hedestam
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
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Sai T. Reddy
3Department of Biosystems Science and Engineering, ETH Zürich
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Jan Albert
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
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Thomas P. Peacock
5Department of Infectious Disease, Imperial College London, London, UK
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Ben Murrell
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
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  • For correspondence: benjamin.murrell@ki.se
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Abstract

Several sublineages of omicron have emerged with additional mutations that may afford further antibody evasion. Here, we characterise the sensitivity of emerging omicron sublineages BA.2.75.2, BA.4.6, and BA.2.10.4 to antibody-mediated neutralisation, and identify extensive escape by BA.2.75.2. BA.2.75.2 was resistant to neutralisation by Evusheld (tixagevimab + cilgavimab), but remained sensitive to bebtelovimab. In recent serum samples from blood donors in Stockholm, Sweden, BA.2.75.2 was neutralised, on average, at titers approximately 6.5-times lower than BA.5, making BA.2.75.2 the most neutralisation resistant variant evaluated to date. These data raise concerns that BA.2.75.2 may effectively evade humoral immunity in the population.

Competing Interest Statement

STR is a cofounder of and held shares in deepCDR Biologics, which has been acquired by Alloy Therapeutics. DJS, GBKH, and BM have intellectual property rights associated with antibodies that neutralise omicron variants. All other authors declare no competing interests.

Footnotes

  • The manuscript has been updated with data from additional sampling time points.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted September 19, 2022.
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Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies
Daniel J. Sheward, Changil Kim, Julian Fischbach, Sandra Muschiol, Roy A. Ehling, Niklas K. Björkström, Gunilla B. Karlsson Hedestam, Sai T. Reddy, Jan Albert, Thomas P. Peacock, Ben Murrell
bioRxiv 2022.09.16.508299; doi: https://doi.org/10.1101/2022.09.16.508299
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Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies
Daniel J. Sheward, Changil Kim, Julian Fischbach, Sandra Muschiol, Roy A. Ehling, Niklas K. Björkström, Gunilla B. Karlsson Hedestam, Sai T. Reddy, Jan Albert, Thomas P. Peacock, Ben Murrell
bioRxiv 2022.09.16.508299; doi: https://doi.org/10.1101/2022.09.16.508299

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