Host genetic background is a barrier to broadly effective vaccine protection: Relevance to BCG and Mycobacterium tuberculosis Infection

Rocky Lai; Diana Gong; Travis Williams; Abiola F. Ogunsola; Kelly Cavallo; Cecilia S. Lindestam Arlehamn; Sarah Acolatse; Gillian L. Beamer; Martin T. Ferris; Christopher M. Sassetti; Douglas A. Lauffenburger; Samuel M. Behar

doi:10.1101/2022.09.19.508548

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Host genetic background is a barrier to broadly effective vaccine protection: Relevance to BCG and Mycobacterium tuberculosis Infection

Rocky Lai, Diana Gong, Travis Williams, Abiola F. Ogunsola, Kelly Cavallo, View ORCID ProfileCecilia S. Lindestam Arlehamn, Sarah Acolatse, Gillian L. Beamer, Martin T. Ferris, Christopher M. Sassetti, Douglas A. Lauffenburger, View ORCID ProfileSamuel M. Behar

doi: https://doi.org/10.1101/2022.09.19.508548

Rocky Lai

1Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA

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Diana Gong

2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

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Travis Williams

1Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA

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Abiola F. Ogunsola

1Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA

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Kelly Cavallo

1Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA

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Cecilia S. Lindestam Arlehamn

3Center for infectious disease and vaccine research, La Jolla Institute for Immunology., La Jolla, CA, USA

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ORCID record for Cecilia S. Lindestam Arlehamn

Sarah Acolatse

2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

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Gillian L. Beamer

4Texas Biomedical Research Institute, San Antonio, TX, USA

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Martin T. Ferris

5Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, United States

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Christopher M. Sassetti

1Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA

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Douglas A. Lauffenburger

2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

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Samuel M. Behar

1Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA

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ORCID record for Samuel M. Behar
For correspondence: samuel.behar@umassmed.edu

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Posted November 29, 2022.

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Host genetic background is a barrier to broadly effective vaccine protection: Relevance to BCG and Mycobacterium tuberculosis Infection

Rocky Lai, Diana Gong, Travis Williams, Abiola F. Ogunsola, Kelly Cavallo, Cecilia S. Lindestam Arlehamn, Sarah Acolatse, Gillian L. Beamer, Martin T. Ferris, Christopher M. Sassetti, Douglas A. Lauffenburger, Samuel M. Behar

bioRxiv 2022.09.19.508548; doi: https://doi.org/10.1101/2022.09.19.508548

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