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Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells
View ORCID ProfileJason M. Torres, Han Sun, Vibe Nylander, View ORCID ProfileDamien J. Downes, Martijn van de Bunt, Mark I. McCarthy, View ORCID ProfileJim R. Hughes, Anna L. Gloyn
doi: https://doi.org/10.1101/2022.09.19.508549
Jason M. Torres
1Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK
6Clinical Trial Service Unit and Epidemiological Studies Unit, Oxford Population Health, University of Oxford, OX3 7LF, UK
Han Sun
2Department of Pediatrics, Division of Endocrinology and Diabetes, Stanford University School of Medicine, Stanford, CA 94305, USA
Vibe Nylander
3Oxford Centre for Diabetes Endocrinology & Metabolism, University of Oxford, UK
Damien J. Downes
4Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Martijn van de Bunt
1Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK
3Oxford Centre for Diabetes Endocrinology & Metabolism, University of Oxford, UK
7Cytoki Pharma ApS, Tuborg Boulevard 12, DK-2900 Hellerup, DK
Mark I. McCarthy
1Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK
3Oxford Centre for Diabetes Endocrinology & Metabolism, University of Oxford, UK
8OMNI Human Genetics, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
Jim R. Hughes
4Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
5MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Anna L. Gloyn
1Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK
2Department of Pediatrics, Division of Endocrinology and Diabetes, Stanford University School of Medicine, Stanford, CA 94305, USA
3Oxford Centre for Diabetes Endocrinology & Metabolism, University of Oxford, UK
Posted September 19, 2022.
Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells
Jason M. Torres, Han Sun, Vibe Nylander, Damien J. Downes, Martijn van de Bunt, Mark I. McCarthy, Jim R. Hughes, Anna L. Gloyn
bioRxiv 2022.09.19.508549; doi: https://doi.org/10.1101/2022.09.19.508549
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