In situ single-cell analysis of canonical breast cancer biomarkers: phenotypic heterogeneity and implications on response to HER2 targeting agents

Garazi Serna; Eloy García; Roberta Fasani; Xavier Guardia; Tomas Pascual; Laia Paré; Fiorella Ruiz-Pace; Antonio Llombart-Cussac; Javier Cortes; Aleix Prat; Paolo Nuciforo

doi:10.1101/2022.09.21.508826

New Results

In situ single-cell analysis of canonical breast cancer biomarkers: phenotypic heterogeneity and implications on response to HER2 targeting agents

Garazi Serna, Eloy García, Roberta Fasani, Xavier Guardia, Tomas Pascual, Laia Paré, Fiorella Ruiz-Pace, Antonio Llombart-Cussac, Javier Cortes, Aleix Prat, Paolo Nuciforo

doi: https://doi.org/10.1101/2022.09.21.508826

Garazi Serna

1Molecular oncology group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Eloy García

2Department of Mathematics and Informatics, University of Barcelona, Barcelona, Spain

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Roberta Fasani

1Molecular oncology group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Xavier Guardia

1Molecular oncology group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tomas Pascual

3Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain

4Department of Medical Oncology, Hospital Clínic de Barcelona, Barcelona, Spain

5SOLTI Breast Cancer Research Group, Barcelona, Spain

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Laia Paré

6Reveal Genomics, Barcelona, Spain

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Fiorella Ruiz-Pace

7Oncology Data Science Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Antonio Llombart-Cussac

8Department of Medical Oncology, Hospital Arnau de Vilanova, Valencia, Spain; FISABIO, Universidad Católica de Valencia, Spain

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Javier Cortes

9International Breast Cancer Center (IBCC), Quirónsalud Group, Barcelona, Spain; Medica Scientia Innovation Research (MEDSIR), Barcelona, Spain; Universidad Europea de Madrid, Faculty of Biomedical and Health Sciences, Department of Medicine, Madrid, Spain

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Aleix Prat

3Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain

4Department of Medical Oncology, Hospital Clínic de Barcelona, Barcelona, Spain

5SOLTI Breast Cancer Research Group, Barcelona, Spain

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Paolo Nuciforo

1Molecular oncology group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain

5SOLTI Breast Cancer Research Group, Barcelona, Spain

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: pnuciforo@vhio.net

Abstract
Full Text
Info/History
Metrics
Supplementary material
Preview PDF

Article usage

Article usage: September 2022 to May 2023

	Abstract	Full	Pdf
Sep 2022	414	7	50
Oct 2022	119	6	23
Nov 2022	66	3	16
Dec 2022	32	6	9
Jan 2023	32	5	5
Feb 2023	54	14	27
Mar 2023	30	6	16
Apr 2023	35	4	11
May 2023	21	6	6

View the discussion thread.

PreviousNext

Posted September 22, 2022.

Download PDF

Supplementary Material

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following In situ single-cell analysis of canonical breast cancer biomarkers: phenotypic heterogeneity and implications on response to HER2 targeting agents

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

In situ single-cell analysis of canonical breast cancer biomarkers: phenotypic heterogeneity and implications on response to HER2 targeting agents

Garazi Serna, Eloy García, Roberta Fasani, Xavier Guardia, Tomas Pascual, Laia Paré, Fiorella Ruiz-Pace, Antonio Llombart-Cussac, Javier Cortes, Aleix Prat, Paolo Nuciforo

bioRxiv 2022.09.21.508826; doi: https://doi.org/10.1101/2022.09.21.508826

Share This Article:

Citation Tools

In situ single-cell analysis of canonical breast cancer biomarkers: phenotypic heterogeneity and implications on response to HER2 targeting agents

Garazi Serna, Eloy García, Roberta Fasani, Xavier Guardia, Tomas Pascual, Laia Paré, Fiorella Ruiz-Pace, Antonio Llombart-Cussac, Javier Cortes, Aleix Prat, Paolo Nuciforo

bioRxiv 2022.09.21.508826; doi: https://doi.org/10.1101/2022.09.21.508826

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Tweet Widget
Facebook Like
Google Plus One

Subject Area

Pathology

Subject Areas

All Articles

Animal Behavior and Cognition (4369)
Biochemistry (9550)
Bioengineering (7071)
Bioinformatics (24774)
Biophysics (12566)
Cancer Biology (9925)
Cell Biology (14299)
Clinical Trials (138)
Developmental Biology (7931)
Ecology (12077)
Epidemiology (2067)
Evolutionary Biology (15957)
Genetics (10904)
Genomics (14708)
Immunology (9847)
Microbiology (23585)
Molecular Biology (9456)
Neuroscience (50699)
Paleontology (369)
Pathology (1535)
Pharmacology and Toxicology (2674)
Physiology (4001)
Plant Biology (8642)
Scientific Communication and Education (1505)
Synthetic Biology (2388)
Systems Biology (6415)
Zoology (1345)