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Genetic risk for Multiple Sclerosis originated in Pastoralist Steppe populations
View ORCID ProfileWilliam Barrie, Yaoling Yang, View ORCID ProfileKathrine E. Attfield, View ORCID ProfileEvan Irving-Pease, View ORCID ProfileGabriele Scorrano, View ORCID ProfileLise Torp Jensen, View ORCID ProfileAngelos P. Armen, View ORCID ProfileEvangelos Antonios Dimopoulos, View ORCID ProfileAaron Stern, View ORCID ProfileAlba Refoyo-Martinez, Abigail Ramsøe, View ORCID ProfileCharleen Gaunitz, View ORCID ProfileFabrice Demeter, View ORCID ProfileMarie Louise S. Jørkov, Stig Bermann Møller, Bente Springborg, View ORCID ProfileLutz Klassen, Inger Marie Hyldgård, Niels Wickmann, View ORCID ProfileLasse Vinner, View ORCID ProfileThorfinn Sand Korneliussen, View ORCID ProfileMartin Sikora, View ORCID ProfileKristian Kristiansen, Santiago Rodriguez, View ORCID ProfileRasmus Nielsen, Astrid K. N. Iversen, View ORCID ProfileDaniel J. Lawson, View ORCID ProfileLars Fugger, View ORCID ProfileEske Willerslev
doi: https://doi.org/10.1101/2022.09.23.509097
William Barrie
1Department of Zoology, University of Cambridge, Cambridge, UK
Yaoling Yang
2Department of Statistical Sciences, School of Mathematics, University of Bristol, Bristol, UK
3Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK
Kathrine E. Attfield
4Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
Evan Irving-Pease
5Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark
Gabriele Scorrano
5Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark
Lise Torp Jensen
6Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Angelos P. Armen
4Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
Evangelos Antonios Dimopoulos
7Pathogen Genomics and Evolution Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
Aaron Stern
8Department of Integrative Biology, University of California, Berkeley
Alba Refoyo-Martinez
5Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark
Abigail Ramsøe
5Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark
Charleen Gaunitz
5Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark
Fabrice Demeter
5Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark
Marie Louise S. Jørkov
9Laboratory of Biological Anthropology, Department of Forensic Medicine, University of Copenhagen, Denmark
Stig Bermann Møller
10Ålborg Historiske Museum, Nordjyske Museer, Vang Mark 25, 9380 Vestbjerg, Denmark
Bente Springborg
10Ålborg Historiske Museum, Nordjyske Museer, Vang Mark 25, 9380 Vestbjerg, Denmark
Lutz Klassen
11Museum Østdanmark - Djursland og Randers. Stemannsgade 2, DK-8900 Randers C, Denmark
Inger Marie Hyldgård
11Museum Østdanmark - Djursland og Randers. Stemannsgade 2, DK-8900 Randers C, Denmark
Niels Wickmann
12Museum Vestsjælland, Forten 10, 4300 Holbæk, Denmark
Lasse Vinner
5Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark
Thorfinn Sand Korneliussen
5Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark
Martin Sikora
5Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark
Kristian Kristiansen
5Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark
13Department of Historical Studies, University of Gothenburg, SE-41255, Gothenburg, Sweden
Santiago Rodriguez
3Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK
Rasmus Nielsen
5Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark
8Department of Integrative Biology, University of California, Berkeley
Astrid K. N. Iversen
4Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
Daniel J. Lawson
2Department of Statistical Sciences, School of Mathematics, University of Bristol, Bristol, UK
3Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK
Lars Fugger
4Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
14MRC Human Immunology Unit, John Radcliffe Hospital, University of Oxford, Oxford, UK
Eske Willerslev
1Department of Zoology, University of Cambridge, Cambridge, UK
5Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark
Posted September 26, 2022.
Genetic risk for Multiple Sclerosis originated in Pastoralist Steppe populations
William Barrie, Yaoling Yang, Kathrine E. Attfield, Evan Irving-Pease, Gabriele Scorrano, Lise Torp Jensen, Angelos P. Armen, Evangelos Antonios Dimopoulos, Aaron Stern, Alba Refoyo-Martinez, Abigail Ramsøe, Charleen Gaunitz, Fabrice Demeter, Marie Louise S. Jørkov, Stig Bermann Møller, Bente Springborg, Lutz Klassen, Inger Marie Hyldgård, Niels Wickmann, Lasse Vinner, Thorfinn Sand Korneliussen, Martin Sikora, Kristian Kristiansen, Santiago Rodriguez, Rasmus Nielsen, Astrid K. N. Iversen, Daniel J. Lawson, Lars Fugger, Eske Willerslev
bioRxiv 2022.09.23.509097; doi: https://doi.org/10.1101/2022.09.23.509097
Genetic risk for Multiple Sclerosis originated in Pastoralist Steppe populations
William Barrie, Yaoling Yang, Kathrine E. Attfield, Evan Irving-Pease, Gabriele Scorrano, Lise Torp Jensen, Angelos P. Armen, Evangelos Antonios Dimopoulos, Aaron Stern, Alba Refoyo-Martinez, Abigail Ramsøe, Charleen Gaunitz, Fabrice Demeter, Marie Louise S. Jørkov, Stig Bermann Møller, Bente Springborg, Lutz Klassen, Inger Marie Hyldgård, Niels Wickmann, Lasse Vinner, Thorfinn Sand Korneliussen, Martin Sikora, Kristian Kristiansen, Santiago Rodriguez, Rasmus Nielsen, Astrid K. N. Iversen, Daniel J. Lawson, Lars Fugger, Eske Willerslev
bioRxiv 2022.09.23.509097; doi: https://doi.org/10.1101/2022.09.23.509097
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