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Nicotinamide-N-methyltransferase is essential for SAM and 1-methylnicotinamide homeostasis in the AML12 hepatocyte cell line

Mayuko Yoda, Rin Mizuno, Yoshihiro Izumi, Masatomo Takahashi, Takeshi Bamba, Shinpei Kawaoka
doi: https://doi.org/10.1101/2022.09.25.509348
Mayuko Yoda
1Department of Integrative Bioanalytics, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai 980-8575, Japan
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Rin Mizuno
2Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan
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Yoshihiro Izumi
3Division of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan
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Masatomo Takahashi
3Division of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan
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Takeshi Bamba
3Division of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan
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Shinpei Kawaoka
1Department of Integrative Bioanalytics, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai 980-8575, Japan
2Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan
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  • For correspondence: kawaokashinpei@gmail.com
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Article Information

doi 
https://doi.org/10.1101/2022.09.25.509348
History 
  • September 27, 2022.

Article Versions

  • Version 1 (September 25, 2022 - 20:14).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Mayuko Yoda1,
  2. Rin Mizuno2,
  3. Yoshihiro Izumi3,
  4. Masatomo Takahashi3,
  5. Takeshi Bamba3 and
  6. Shinpei Kawaoka1,2,*
  1. 1Department of Integrative Bioanalytics, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai 980-8575, Japan
  2. 2Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan
  3. 3Division of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan
  1. ↵*Corresponding Author: Shinpei Kawaoka, Ph.D. Department of Integrative Bioanalytics, Institute of Development, Aging and Cancer (IDAC), Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan, TEL: +81-22-717-8568, Email: kawaokashinpei{at}gmail.com, Inter-Organ Communication Research Team, Institute for Life and Medical Sciences, Kyoto University, 53 Shogoin-kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan, TEL: +81-75-751-4804, Email: kawaokashinpei{at}gmail.com
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Posted September 27, 2022.
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Nicotinamide-N-methyltransferase is essential for SAM and 1-methylnicotinamide homeostasis in the AML12 hepatocyte cell line
Mayuko Yoda, Rin Mizuno, Yoshihiro Izumi, Masatomo Takahashi, Takeshi Bamba, Shinpei Kawaoka
bioRxiv 2022.09.25.509348; doi: https://doi.org/10.1101/2022.09.25.509348
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Nicotinamide-N-methyltransferase is essential for SAM and 1-methylnicotinamide homeostasis in the AML12 hepatocyte cell line
Mayuko Yoda, Rin Mizuno, Yoshihiro Izumi, Masatomo Takahashi, Takeshi Bamba, Shinpei Kawaoka
bioRxiv 2022.09.25.509348; doi: https://doi.org/10.1101/2022.09.25.509348

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