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Intrinsic neural timescales in the temporal lobe support an auditory processing hierarchy

View ORCID ProfileRiccardo Cusinato, Sigurd L. Alnes, Ellen van Maren, Ida Boccalaro, Debora Ledergerber, View ORCID ProfileAntoine Adamantidis, View ORCID ProfileLukas L. Imbach, View ORCID ProfileKaspar Schindler, View ORCID ProfileMaxime O. Baud, View ORCID ProfileAthina Tzovara
doi: https://doi.org/10.1101/2022.09.27.509695
Riccardo Cusinato
1Institute of Computer Science, University of Bern, Switzerland
2Center for Experimental Neurology - Sleep Wake Epilepsy Center - NeuroTec, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
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  • ORCID record for Riccardo Cusinato
Sigurd L. Alnes
1Institute of Computer Science, University of Bern, Switzerland
2Center for Experimental Neurology - Sleep Wake Epilepsy Center - NeuroTec, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
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Ellen van Maren
2Center for Experimental Neurology - Sleep Wake Epilepsy Center - NeuroTec, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
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Ida Boccalaro
2Center for Experimental Neurology - Sleep Wake Epilepsy Center - NeuroTec, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
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Debora Ledergerber
3Swiss Epilepsy Center, Klinik Lengg, Zurich, Switzerland
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Antoine Adamantidis
2Center for Experimental Neurology - Sleep Wake Epilepsy Center - NeuroTec, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
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Lukas L. Imbach
3Swiss Epilepsy Center, Klinik Lengg, Zurich, Switzerland
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  • ORCID record for Lukas L. Imbach
Kaspar Schindler
2Center for Experimental Neurology - Sleep Wake Epilepsy Center - NeuroTec, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
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Maxime O. Baud
2Center for Experimental Neurology - Sleep Wake Epilepsy Center - NeuroTec, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
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Athina Tzovara
1Institute of Computer Science, University of Bern, Switzerland
2Center for Experimental Neurology - Sleep Wake Epilepsy Center - NeuroTec, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
4Helen Wills Neuroscience Institute, University of California Berkeley, USA
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  • For correspondence: athina.tz@gmail.com
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Abstract

During rest, intrinsic neural dynamics manifest at multiple timescales, which progressively increase along visual and somatosensory hierarchies. Theoretically, intrinsic timescales are thought to facilitate processing of external stimuli at multiple stages. However, direct links between timescales at rest and sensory processing, as well as translation to the auditory system are lacking. Here, we used intracranial electroencephalography in humans to show that in the auditory network, intrinsic neural timescales progressively increase, while the spectral slope flattens, from temporal to entorhinal cortex, hippocampus, and amygdala. Within the neocortex, intrinsic timescales exhibit spatial gradients that follow the temporal lobe anatomy. Crucially, intrinsic timescales at rest can explain the latency of auditory responses: as intrinsic timescales increase, so do the single-electrode response onset and peak latencies. Our results suggest that the human auditory network exhibits a repertoire of intrinsic neural dynamics, which manifest in cortical gradients with millimeter resolution and may provide a variety of temporal windows to support auditory processing.

Competing Interest Statement

MOB holds shares with Epios SA, a medical device company based in Geneva.

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Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted September 28, 2022.
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Intrinsic neural timescales in the temporal lobe support an auditory processing hierarchy
Riccardo Cusinato, Sigurd L. Alnes, Ellen van Maren, Ida Boccalaro, Debora Ledergerber, Antoine Adamantidis, Lukas L. Imbach, Kaspar Schindler, Maxime O. Baud, Athina Tzovara
bioRxiv 2022.09.27.509695; doi: https://doi.org/10.1101/2022.09.27.509695
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Intrinsic neural timescales in the temporal lobe support an auditory processing hierarchy
Riccardo Cusinato, Sigurd L. Alnes, Ellen van Maren, Ida Boccalaro, Debora Ledergerber, Antoine Adamantidis, Lukas L. Imbach, Kaspar Schindler, Maxime O. Baud, Athina Tzovara
bioRxiv 2022.09.27.509695; doi: https://doi.org/10.1101/2022.09.27.509695

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