Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic mice

Alexandra von Strempel; Anna S. Weiss; Johannes Wittmann; Marta Salvado Silva; Diana Ring; Esther Wortmann; Thomas Clavel; Laurent Debarbieux; Karin Kleigrewe; Bärbel Stecher

doi:10.1101/2022.09.28.509654

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Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic mice

View ORCID ProfileAlexandra von Strempel, View ORCID ProfileAnna S. Weiss, Johannes Wittmann, Marta Salvado Silva, Diana Ring, Esther Wortmann, Thomas Clavel, View ORCID ProfileLaurent Debarbieux, Karin Kleigrewe, View ORCID ProfileBärbel Stecher

doi: https://doi.org/10.1101/2022.09.28.509654

Alexandra von Strempel

1Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU Munich, Munich, Germany

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Anna S. Weiss

1Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU Munich, Munich, Germany

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Johannes Wittmann

2Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany

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Marta Salvado Silva

1Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU Munich, Munich, Germany

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Diana Ring

1Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU Munich, Munich, Germany

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Esther Wortmann

3Functional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany

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Thomas Clavel

3Functional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany

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Laurent Debarbieux

4Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, Paris 75015, France

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Karin Kleigrewe

5Bavarian Center for Biomolecular Mass Spectrometry, TUM School of Life Sciences, Technical University of Munich, Freising, Germany

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Bärbel Stecher

1Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU Munich, Munich, Germany

6German Center for Infection Research (DZIF), partner site LMU Munich, Munich, Germany

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For correspondence: stecher@mvp.lmu.de

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Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic mice

Alexandra von Strempel, Anna S. Weiss, Johannes Wittmann, Marta Salvado Silva, Diana Ring, Esther Wortmann, Thomas Clavel, Laurent Debarbieux, Karin Kleigrewe, Bärbel Stecher

bioRxiv 2022.09.28.509654; doi: https://doi.org/10.1101/2022.09.28.509654

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Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic mice

Alexandra von Strempel, Anna S. Weiss, Johannes Wittmann, Marta Salvado Silva, Diana Ring, Esther Wortmann, Thomas Clavel, Laurent Debarbieux, Karin Kleigrewe, Bärbel Stecher

bioRxiv 2022.09.28.509654; doi: https://doi.org/10.1101/2022.09.28.509654

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