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- September 28, 2022.
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Author Information
- Eric Van Buren1,2,
- Giorgia Radicioni3,
- Sarah Lester4,
- Wanda K. O’Neal3,
- Hong Dang3,
- Silva Kasela5,6,
- Suresh Garudadri7,
- Jeffrey L. Curtis8,9,
- Meilan Han8,
- Jerry Krishnan10,
- Emily S. Wan11,12,
- Edwin K. Silverman11,
- Annette Hastie13,
- Victor E. Ortega14,
- Tuuli Lappalainen5,6,
- Stephanie A. Christenson7,
- Yun Li1,4,
- Michael H. Cho11,
- Mehmet Kesimer3 and
- Samir N. P. Kelada3,4,*
- 1Department of Biostatistics, University of North Carolina, Chapel Hill, NC
- 2Department of Biostatistics, Harvard T.H. Chan School of Public Health, MA
- 3Marsico Lung Institute, University of North Carolina, Chapel Hill, NC
- 4Department of Genetics, University of North Carolina, Chapel Hill, NC
- 5New York Genome Center, New York, NY, USA
- 6Department of Systems Biology, Columbia University, New York, NY, USA
- 7Division of Pulmonary, Critical Care, Allergy, & Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
- 8Pulmonary & Critical Care Medicine Division, University of Michigan, Ann Arbor, MI
- 9Medical Service, VA Ann Arbor Healthcare System, Ann Arbor, MI
- 10Breathe Chicago Center, University of Illinois Chicago
- 11Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA
- 12VA Boston Healthcare System, Jamaica Plain, MA
- 13Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC
- 14Department of Internal Medicine, Division of Respiratory Medicine, Mayo Clinic, Scottsdale, AZ
- ↵*Corresponding Author
Samir Kelada, PhD MPH, Department of Genetics, 120 Mason Farm Road, Room 5072, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, 919-962-2148, samir_kelada{at}med.unc.edu
Author Contributions: SNPK had full access to all of the data in the study and takes responsibility for the integrity of the data and accuracy of the analysis. EVB, GR, WKO, ESW, EKS, YL, MHC and SNPK contributed to the conception and design of the study. GR, SR, JLC, MH, JK, ESW, EKS, AH, VEO, TL, SAC, MHC, and MK contributed to the acquisition of the data. EVB, GR, WKO, HD, SK, YL, MHC, and SNPK contributed to data analysis. EVB, JLC, SK, ESW, EKS, AH, VEO, YL, MHC and SNPK contributed to the drafting of the manuscript. All of the authors approved this version of the manuscript to be published.
Posted September 28, 2022.
Genetic Regulators of Sputum Mucin Concentration and Their Associations with COPD Phenotypes
