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Location of CD39+ T cell sub-populations within tumours predict differential outcomes in non-small cell lung cancer

View ORCID ProfileLilian Koppensteiner, View ORCID ProfileLayla Mathieson, View ORCID ProfileSamuel Pattle, View ORCID ProfileDavid A Dorward, View ORCID ProfileRichard O’Connor, View ORCID ProfileAhsan Akram
doi: https://doi.org/10.1101/2022.09.29.509921
Lilian Koppensteiner
1Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh, United Kingdom, EH16 4TJ
2Translational Healthcare Technologies Group, Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh, United Kingdom, EH16 4TJ
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  • ORCID record for Lilian Koppensteiner
  • For correspondence: l.koppensteiner@sms.ed.ac.uk ahsan.akram@ed.ac.uk
Layla Mathieson
1Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh, United Kingdom, EH16 4TJ
2Translational Healthcare Technologies Group, Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh, United Kingdom, EH16 4TJ
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Samuel Pattle
3Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
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David A Dorward
1Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh, United Kingdom, EH16 4TJ
3Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
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Richard O’Connor
1Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh, United Kingdom, EH16 4TJ
2Translational Healthcare Technologies Group, Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh, United Kingdom, EH16 4TJ
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Ahsan Akram
1Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh, United Kingdom, EH16 4TJ
2Translational Healthcare Technologies Group, Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh, United Kingdom, EH16 4TJ
4Cancer Research UK Edinburgh Centre, Institute of Genetics & Molecular Medicine, The University of Edinburgh, Crewe Road South, Edinburgh, United Kingdom, EH4 2XR
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  • ORCID record for Ahsan Akram
  • For correspondence: l.koppensteiner@sms.ed.ac.uk ahsan.akram@ed.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2022.09.29.509921
History 
  • September 30, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Lilian Koppensteiner1,2,#,
  2. Layla Mathieson1,2,
  3. Samuel Pattle3,
  4. David A Dorward1,3,
  5. Richard O’Connor1,2 and
  6. Ahsan Akram1,2,4,#
  1. 1Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh, United Kingdom, EH16 4TJ
  2. 2Translational Healthcare Technologies Group, Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh BioQuarter, Edinburgh, United Kingdom, EH16 4TJ
  3. 3Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
  4. 4Cancer Research UK Edinburgh Centre, Institute of Genetics & Molecular Medicine, The University of Edinburgh, Crewe Road South, Edinburgh, United Kingdom, EH4 2XR
  1. ↵#Correspondence to: Lilian Koppenstienter (l.koppensteiner{at}sms.ed.ac.uk) or Ahsan Akram (ahsan.akram{at}ed.ac.uk)
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Posted September 30, 2022.
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Location of CD39+ T cell sub-populations within tumours predict differential outcomes in non-small cell lung cancer
Lilian Koppensteiner, Layla Mathieson, Samuel Pattle, David A Dorward, Richard O’Connor, Ahsan Akram
bioRxiv 2022.09.29.509921; doi: https://doi.org/10.1101/2022.09.29.509921
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Location of CD39+ T cell sub-populations within tumours predict differential outcomes in non-small cell lung cancer
Lilian Koppensteiner, Layla Mathieson, Samuel Pattle, David A Dorward, Richard O’Connor, Ahsan Akram
bioRxiv 2022.09.29.509921; doi: https://doi.org/10.1101/2022.09.29.509921

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