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Positive allosteric modulation of α5-GABA A Receptor in the 5XFAD mouse model has cognitive and neurotrophic benefits

Ashley M. Bernardo, Michael Marcotte, Kayla Wong, Dishary Sharmin, Kamal Prandey, James M. Cook, Etienne Sibille, View ORCID ProfileThomas D. Prevot
doi: https://doi.org/10.1101/2022.09.30.510361
Ashley M. Bernardo
1Campbell Family Mental Health Research Institute of CAMH, Toronto, Canada
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Michael Marcotte
1Campbell Family Mental Health Research Institute of CAMH, Toronto, Canada
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Kayla Wong
1Campbell Family Mental Health Research Institute of CAMH, Toronto, Canada
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Dishary Sharmin
2Department of Chemistry and Biochemistry, University of Wisconsin–Milwaukee, Milwaukee, USA
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Kamal Prandey
2Department of Chemistry and Biochemistry, University of Wisconsin–Milwaukee, Milwaukee, USA
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James M. Cook
2Department of Chemistry and Biochemistry, University of Wisconsin–Milwaukee, Milwaukee, USA
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Etienne Sibille
1Campbell Family Mental Health Research Institute of CAMH, Toronto, Canada
3Department of Psychiatry, University of Toronto, Toronto, Canada
4Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada
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Thomas D. Prevot
1Campbell Family Mental Health Research Institute of CAMH, Toronto, Canada
3Department of Psychiatry, University of Toronto, Toronto, Canada
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  • ORCID record for Thomas D. Prevot
  • For correspondence: thomas.prevot@camh.ca
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Article Information

doi 
https://doi.org/10.1101/2022.09.30.510361
History 
  • October 3, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Ashley M. Bernardo1,
  2. Michael Marcotte1,
  3. Kayla Wong1,
  4. Dishary Sharmin2,
  5. Kamal Prandey2,
  6. James M. Cook2,
  7. Etienne Sibille1,3,4 and
  8. Thomas D. Prevot1,3,*
  1. 1Campbell Family Mental Health Research Institute of CAMH, Toronto, Canada
  2. 2Department of Chemistry and Biochemistry, University of Wisconsin–Milwaukee, Milwaukee, USA
  3. 3Department of Psychiatry, University of Toronto, Toronto, Canada
  4. 4Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada
  1. ↵*Corresponding Author Thomas D. Prevot, Ph.D., CAMH, 250 College Street, room 131, Toronto, ON M5T 1R8, Canada, Tel: 416-535-8501, ext 33785; E-mail: thomas.prevot{at}camh.ca
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Posted October 03, 2022.
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Positive allosteric modulation of α5-GABA A Receptor in the 5XFAD mouse model has cognitive and neurotrophic benefits
Ashley M. Bernardo, Michael Marcotte, Kayla Wong, Dishary Sharmin, Kamal Prandey, James M. Cook, Etienne Sibille, Thomas D. Prevot
bioRxiv 2022.09.30.510361; doi: https://doi.org/10.1101/2022.09.30.510361
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Positive allosteric modulation of α5-GABA A Receptor in the 5XFAD mouse model has cognitive and neurotrophic benefits
Ashley M. Bernardo, Michael Marcotte, Kayla Wong, Dishary Sharmin, Kamal Prandey, James M. Cook, Etienne Sibille, Thomas D. Prevot
bioRxiv 2022.09.30.510361; doi: https://doi.org/10.1101/2022.09.30.510361

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