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Arena3Dweb: Interactive 3D visualization of multilayered networks supporting multiple directional information channels, clustering analysis and application integration

Maria Kokoli, View ORCID ProfileEvangelos Karatzas, View ORCID ProfileFotis A. Baltoumas, View ORCID ProfileReinhard Schneider, View ORCID ProfileEvangelos Pafilis, View ORCID ProfileSavvas Paragkamian, View ORCID ProfileNadezhda T. Doncheva, View ORCID ProfileLars Juhl Jensen, View ORCID ProfileGeorgios A. Pavlopoulos
doi: https://doi.org/10.1101/2022.10.01.510435
Maria Kokoli
1Institute for Fundamental Biomedical Research, BSRC “Alexander Fleming”, Vari, 16672, Greece
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Evangelos Karatzas
1Institute for Fundamental Biomedical Research, BSRC “Alexander Fleming”, Vari, 16672, Greece
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  • For correspondence: pavlopoulos@fleming.gr karatzas@fleming.gr
Fotis A. Baltoumas
1Institute for Fundamental Biomedical Research, BSRC “Alexander Fleming”, Vari, 16672, Greece
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Reinhard Schneider
2University of Luxembourg, Luxembourg Centre for Systems Biomedicine, Bioinformatics Core, Esch-sur-Alzette, Luxembourg
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Evangelos Pafilis
3Institute of Marine Biology, Biotechnology and Aquaculture (IMBBC), Hellenic Centre for Marine Research (HCMR), Former U.S. Base of Gournes, Heraklion, 71003, Greece
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Savvas Paragkamian
3Institute of Marine Biology, Biotechnology and Aquaculture (IMBBC), Hellenic Centre for Marine Research (HCMR), Former U.S. Base of Gournes, Heraklion, 71003, Greece
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Nadezhda T. Doncheva
4Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen N, DK- 2200, Denmark
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Lars Juhl Jensen
4Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen N, DK- 2200, Denmark
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Georgios A. Pavlopoulos
1Institute for Fundamental Biomedical Research, BSRC “Alexander Fleming”, Vari, 16672, Greece
5Center of New Biotechnologies & Precision Medicine, Medical School, National and Kapodistrian University of Athens, Athens, 11527, Greece
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  • ORCID record for Georgios A. Pavlopoulos
  • For correspondence: pavlopoulos@fleming.gr karatzas@fleming.gr
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ABSTRACT

Arena3Dweb is an interactive web tool that visualizes multi-layered networks in 3D space. In this update, Arena3Dweb supports directed networks as well as up to nine different types of connections between pairs of nodes with the use of Bézier curves. It comes with different color schemes (light/gray/dark mode), custom channel coloring, four node clustering algorithms which one can run on-the-fly, visualization in VR mode and predefined layer layouts (zig-zag, star and cube). This update also includes enhanced navigation controls (mouse orbit controls, layer dragging and layer/node selection), while its newly developed API allows integration with external applications as well as saving and loading of sessions in JSON format. Finally, a dedicated Cytoscape app has been developed, through which users can automatically send their 2D networks from Cytoscape to Arena3Dweb for 3D multi-layer visualization. Arena3Dweb is accessible at http://arena3d.pavlopouloslab.info or http://arena3d.org

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵& The authors wish to be known that the first two authors should be regarded as joint First Authors

  • Section "Integration with Cytoscape" rephrased

  • http://arena3d.org

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted October 05, 2022.
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Arena3Dweb: Interactive 3D visualization of multilayered networks supporting multiple directional information channels, clustering analysis and application integration
Maria Kokoli, Evangelos Karatzas, Fotis A. Baltoumas, Reinhard Schneider, Evangelos Pafilis, Savvas Paragkamian, Nadezhda T. Doncheva, Lars Juhl Jensen, Georgios A. Pavlopoulos
bioRxiv 2022.10.01.510435; doi: https://doi.org/10.1101/2022.10.01.510435
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Arena3Dweb: Interactive 3D visualization of multilayered networks supporting multiple directional information channels, clustering analysis and application integration
Maria Kokoli, Evangelos Karatzas, Fotis A. Baltoumas, Reinhard Schneider, Evangelos Pafilis, Savvas Paragkamian, Nadezhda T. Doncheva, Lars Juhl Jensen, Georgios A. Pavlopoulos
bioRxiv 2022.10.01.510435; doi: https://doi.org/10.1101/2022.10.01.510435

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