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Integrative single cell and spatial transcriptomics of colorectal cancer reveals multicellular functional units that support tumor progression
Inbal Avraham-Davidi, Simon Mages, Johanna Klughammer, Noa Moriel, Shinya Imada, Matan Hofree, Evan Murray, Jonathan Chen, Karin Pelka, Arnav Mehta, Genevieve M. Boland, Toni Delorey, Leah Caplan, Danielle Dionne, Itay Tirosh, Nir Hacohen, Fei Chen, Omer Yilmaz, Jatin Roper, Orit Rozenblatt-Rosen, Mor Nitzan, Aviv Regev
doi: https://doi.org/10.1101/2022.10.02.508492
Inbal Avraham-Davidi
1Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Simon Mages
1Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
2Gene Center and Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany
Johanna Klughammer
1Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
2Gene Center and Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany
Noa Moriel
3School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
Shinya Imada
4Department of Biology at MIT, Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA
Matan Hofree
1Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Evan Murray
5Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA
Jonathan Chen
5Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA
6Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA
7Department of Pathology, MGH, Boston, MA, USA
Karin Pelka
5Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA
6Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA
8Gladstone-UCSF Institute of Genomic Immunology, Gladstone Institutes, CA, USA
9Department of Microbiology and Immunology, UCSF, CA, USA
Arnav Mehta
5Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA
6Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA
10Dana Farber Cancer Institute, Boston, MA, USA
Genevieve M. Boland
5Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA
11Department of Surgery, MGH, Boston, MA, USA
Toni Delorey
1Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Leah Caplan
1Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Danielle Dionne
1Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Itay Tirosh
12Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
Nir Hacohen
5Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA
6Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA
Fei Chen
5Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA
13Harvard Stem Cell and Regenerative Biology, Cambridge MA, USA
Omer Yilmaz
4Department of Biology at MIT, Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA
14Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
Jatin Roper
4Department of Biology at MIT, Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA
15Department of Medicine, Division of Gastroenterology, Duke University, Durham, NC, USA
16Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA
Orit Rozenblatt-Rosen
1Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
17Genentech, 1 DNA Way, South San Francisco, CA, USA
Mor Nitzan
3School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel
18Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem, Israel
19Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
Aviv Regev
1Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA
17Genentech, 1 DNA Way, South San Francisco, CA, USA
20Massachusetts Institute of Technology, Cambridge, MA, USA
Article usage
Posted October 02, 2022.
Integrative single cell and spatial transcriptomics of colorectal cancer reveals multicellular functional units that support tumor progression
Inbal Avraham-Davidi, Simon Mages, Johanna Klughammer, Noa Moriel, Shinya Imada, Matan Hofree, Evan Murray, Jonathan Chen, Karin Pelka, Arnav Mehta, Genevieve M. Boland, Toni Delorey, Leah Caplan, Danielle Dionne, Itay Tirosh, Nir Hacohen, Fei Chen, Omer Yilmaz, Jatin Roper, Orit Rozenblatt-Rosen, Mor Nitzan, Aviv Regev
bioRxiv 2022.10.02.508492; doi: https://doi.org/10.1101/2022.10.02.508492
Integrative single cell and spatial transcriptomics of colorectal cancer reveals multicellular functional units that support tumor progression
Inbal Avraham-Davidi, Simon Mages, Johanna Klughammer, Noa Moriel, Shinya Imada, Matan Hofree, Evan Murray, Jonathan Chen, Karin Pelka, Arnav Mehta, Genevieve M. Boland, Toni Delorey, Leah Caplan, Danielle Dionne, Itay Tirosh, Nir Hacohen, Fei Chen, Omer Yilmaz, Jatin Roper, Orit Rozenblatt-Rosen, Mor Nitzan, Aviv Regev
bioRxiv 2022.10.02.508492; doi: https://doi.org/10.1101/2022.10.02.508492
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