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Comparative genomics and phylogenomics of Campylobacter unveil potential novel species and provide insights into niche segregation

View ORCID ProfileSarah Henaut-Jacobs, View ORCID ProfileHemanoel Passarelli-Araujo, View ORCID ProfileThiago M. Venancio
doi: https://doi.org/10.1101/2022.10.11.511782
Sarah Henaut-Jacobs
1Laboratório de Química e Função de Proteínas e Peptídeos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, Brazil
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Hemanoel Passarelli-Araujo
1Laboratório de Química e Função de Proteínas e Peptídeos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, Brazil
2Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
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  • For correspondence: hemanuel.passarelli@gmail.com thiago.venancio@gmail.com
Thiago M. Venancio
1Laboratório de Química e Função de Proteínas e Peptídeos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, Brazil
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  • For correspondence: hemanuel.passarelli@gmail.com thiago.venancio@gmail.com
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Abstract

Campylobacter is a bacterial genus associated with community outbreaks and gastrointestinal symptoms. Studies on Campylobacter generally focus on specific pathogenic species such as C. coli and C. jejuni. Currently, there are thousands of publicly available Campylobacter genomes, allowing a more complete assessment of the genus diversity. In this work, we report a network-based analysis of all available Campylobacter genomes to explore the genus structure and diversity, revealing potentially new species and elucidating genus features. We also hypothesize that the previously established Clade III of C. coli is in fact a novel species (referred here as Campylobacter spp12). Finally, we found a negative correlation between pangenome fluidity and saturation coefficient, with potential implications to the lifestyles of distinct Campylobacter species. Since pangenome analysis depends on the number of available genomes, this correlation could help estimate pangenome metrics of Campylobacter species with less sequenced genomes, helping understand their lifestyle and niche adaptation. Together, our results indicate that the Campylobacter genus should be re-evaluated, with particular attention to the interplay between genome structure and niche segregation.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Parts of the manuscript have been updated with new results and clarifications.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 18, 2023.
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Comparative genomics and phylogenomics of Campylobacter unveil potential novel species and provide insights into niche segregation
Sarah Henaut-Jacobs, Hemanoel Passarelli-Araujo, Thiago M. Venancio
bioRxiv 2022.10.11.511782; doi: https://doi.org/10.1101/2022.10.11.511782
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Comparative genomics and phylogenomics of Campylobacter unveil potential novel species and provide insights into niche segregation
Sarah Henaut-Jacobs, Hemanoel Passarelli-Araujo, Thiago M. Venancio
bioRxiv 2022.10.11.511782; doi: https://doi.org/10.1101/2022.10.11.511782

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