Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA

Laura E. Newman; Nimesha Tadepalle; Sammy Weiser Novak; Cara R. Schiavon; Gladys R. Rojas; Joshua A. Chevez; Ian Lemersal; Michaela Medina; Sienna Rocha; Christina G. Towers; Danielle A. Grotjahn; Uri Manor; Gerald S. Shadel

doi:10.1101/2022.10.12.511955

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Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA

View ORCID ProfileLaura E. Newman, Nimesha Tadepalle, Sammy Weiser Novak, View ORCID ProfileCara R. Schiavon, Gladys R. Rojas, Joshua A. Chevez, Ian Lemersal, Michaela Medina, Sienna Rocha, View ORCID ProfileChristina G. Towers, View ORCID ProfileDanielle A. Grotjahn, View ORCID ProfileUri Manor, View ORCID ProfileGerald S. Shadel

doi: https://doi.org/10.1101/2022.10.12.511955

Laura E. Newman

1Salk Institute for Biological Studies, La Jolla, CA, USA

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Nimesha Tadepalle

1Salk Institute for Biological Studies, La Jolla, CA, USA

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Sammy Weiser Novak

1Salk Institute for Biological Studies, La Jolla, CA, USA

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Cara R. Schiavon

1Salk Institute for Biological Studies, La Jolla, CA, USA

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Gladys R. Rojas

1Salk Institute for Biological Studies, La Jolla, CA, USA

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Joshua A. Chevez

2Division of Biological Sciences, University of California-San Diego, La Jolla, CA, USA

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Ian Lemersal

3La Jolla Institute for Immunology, La Jolla, CA, USA

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Michaela Medina

4The Scripps Research Institute, La Jolla, CA, USA

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Sienna Rocha

1Salk Institute for Biological Studies, La Jolla, CA, USA

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Christina G. Towers

1Salk Institute for Biological Studies, La Jolla, CA, USA

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Danielle A. Grotjahn

4The Scripps Research Institute, La Jolla, CA, USA

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Uri Manor

1Salk Institute for Biological Studies, La Jolla, CA, USA

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Gerald S. Shadel

1Salk Institute for Biological Studies, La Jolla, CA, USA

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For correspondence: gshadel@salk.edu

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Posted October 12, 2022.

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Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA

Laura E. Newman, Nimesha Tadepalle, Sammy Weiser Novak, Cara R. Schiavon, Gladys R. Rojas, Joshua A. Chevez, Ian Lemersal, Michaela Medina, Sienna Rocha, Christina G. Towers, Danielle A. Grotjahn, Uri Manor, Gerald S. Shadel

bioRxiv 2022.10.12.511955; doi: https://doi.org/10.1101/2022.10.12.511955

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