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SARS-CoV-2 infection in domestic rats after transmission from their infected owner

View ORCID ProfileXavier Montagutelli, Bérénice Decaudin, Maxime Beretta, View ORCID ProfileHugo Mouquet, View ORCID ProfileEtienne Simon-Lorière
doi: https://doi.org/10.1101/2022.10.13.512053
Xavier Montagutelli
1Institut Pasteur, Université Paris Cité, Mouse Genetics Laboratory, Paris, France
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  • For correspondence: xavier.montagutelli@pasteur.fr
Bérénice Decaudin
2Service NAC, Centre Hospitalier Vétérinaire Advetia, Vélizy-Villacoublay, France
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Maxime Beretta
3Institut Pasteur, Université Paris Cité, Laboratory of Humoral Immunology, Paris, France
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Hugo Mouquet
3Institut Pasteur, Université Paris Cité, Laboratory of Humoral Immunology, Paris, France
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Etienne Simon-Lorière
4Institut Pasteur, Université Paris Cité, G5 Evolutionary Genomics of RNA Viruses, Paris, France
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Abstract

We report the transmission of SARS-CoV-2 Omicron variant from a COVID-19 symptomatic individual to two domestic rats, one of which developed severe symptoms. Omicron carries several mutations which permit rodent infection. This report demonstrates that pet, and likely wild, rodents could therefore contribute to SARS-CoV-2 spread and evolution.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 13, 2022.
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SARS-CoV-2 infection in domestic rats after transmission from their infected owner
Xavier Montagutelli, Bérénice Decaudin, Maxime Beretta, Hugo Mouquet, Etienne Simon-Lorière
bioRxiv 2022.10.13.512053; doi: https://doi.org/10.1101/2022.10.13.512053
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SARS-CoV-2 infection in domestic rats after transmission from their infected owner
Xavier Montagutelli, Bérénice Decaudin, Maxime Beretta, Hugo Mouquet, Etienne Simon-Lorière
bioRxiv 2022.10.13.512053; doi: https://doi.org/10.1101/2022.10.13.512053

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