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Real-time Detection of Acute Lymphoblastic Leukemia Cells Using Deep Learning

Emma Chen, View ORCID ProfileMikhail Y. Shalaginov, Rory Liao, Tingying Helen Zeng
doi: https://doi.org/10.1101/2022.10.22.513362
Emma Chen
1Acton-Boxborough Regional High School, Acton, MA 01720, USA
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  • For correspondence: 23chene@abschools.org
Mikhail Y. Shalaginov
2Department of Materials Sciences and Engineering, MIT, Cambridge, MA 02139, USA
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  • For correspondence: mys@mit.edu
Rory Liao
3Department of Computer Science and Engineering, Ohio State University, Columbus, OH 43210, USA
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  • For correspondence: liao.675@osu.edu
Tingying Helen Zeng
4Division of Career Education, Academy for Advanced Research and Development, Cambridge, MA 02142, USA
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  • For correspondence: helen.zeng@ardacademy.org mys@mit.edu
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Abstract

Acute lymphoblastic leukemia (ALL) is one of the most common types of cancer among children. It can rapidly become fatal within weeks, hence early diagnosis is critical. Problematically, the ALL diagnosis mainly involves manual blood smear analysis relying on the expertise of medical professionals, which is error-prone and time-consuming. Thus, it is important to develop artificial intelligence tools that will identify leukemic cells from a microscopic image faster, more accurately, and cheaper. Here, we investigate the capabilities of a traditional convolutional neural network (CNN) and You Only Look Once (YOLO) models for real-time detection of leukemic cells. The YOLOv5s model shows 97.2% accuracy for the task of object detection of ALL cells, with the inference speed allowing 80 image frames to be processed per second. These new findings can provide valuable insight in applying real-time object detection algorithms for improving the efficiency of blood cancer diagnosis.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://github.com/echen053/all-cell-detection

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 24, 2022.
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Real-time Detection of Acute Lymphoblastic Leukemia Cells Using Deep Learning
Emma Chen, Mikhail Y. Shalaginov, Rory Liao, Tingying Helen Zeng
bioRxiv 2022.10.22.513362; doi: https://doi.org/10.1101/2022.10.22.513362
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Real-time Detection of Acute Lymphoblastic Leukemia Cells Using Deep Learning
Emma Chen, Mikhail Y. Shalaginov, Rory Liao, Tingying Helen Zeng
bioRxiv 2022.10.22.513362; doi: https://doi.org/10.1101/2022.10.22.513362

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