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Structural basis for the Rad6 activation by the Bre1 N-terminal domain

Meng Shi, Jiaqi Zhao, Mengfei Li, Wei Huang, Xue Bai, Wenxue Zhang, Kai Zhang, Xuefeng Chen, View ORCID ProfileSong Xiang
doi: https://doi.org/10.1101/2022.10.23.513400
Meng Shi
1Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The province and ministry co-sponsored collaborative innovation center for medical epigenetics, Tianjin Medical University, Tianjin 300070, P. R. CHINA
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Jiaqi Zhao
1Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The province and ministry co-sponsored collaborative innovation center for medical epigenetics, Tianjin Medical University, Tianjin 300070, P. R. CHINA
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Mengfei Li
2Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Frontier Science Centre of Immunology and Metabolism, Wuhan University, Wuhan 430072, P. R. CHINA
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Wei Huang
1Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The province and ministry co-sponsored collaborative innovation center for medical epigenetics, Tianjin Medical University, Tianjin 300070, P. R. CHINA
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Xue Bai
1Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The province and ministry co-sponsored collaborative innovation center for medical epigenetics, Tianjin Medical University, Tianjin 300070, P. R. CHINA
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Wenxue Zhang
3Department of Radiation Oncology, Tianjin Medical University General Hospital, Tianjin 300052, P. R. CHINA
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Kai Zhang
1Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The province and ministry co-sponsored collaborative innovation center for medical epigenetics, Tianjin Medical University, Tianjin 300070, P. R. CHINA
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Xuefeng Chen
2Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Frontier Science Centre of Immunology and Metabolism, Wuhan University, Wuhan 430072, P. R. CHINA
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  • For correspondence: xfchen@whu.edu.cn xiangsong@tmu.edu.cn
Song Xiang
1Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The province and ministry co-sponsored collaborative innovation center for medical epigenetics, Tianjin Medical University, Tianjin 300070, P. R. CHINA
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  • ORCID record for Song Xiang
  • For correspondence: xfchen@whu.edu.cn xiangsong@tmu.edu.cn
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Article Information

doi 
https://doi.org/10.1101/2022.10.23.513400
History 
  • October 24, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Meng Shi1,#,
  2. Jiaqi Zhao1,#,
  3. Mengfei Li2,#,
  4. Wei Huang1,
  5. Xue Bai1,
  6. Wenxue Zhang3,
  7. Kai Zhang1,
  8. Xuefeng Chen2,* and
  9. Song Xiang1,*
  1. 1Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The province and ministry co-sponsored collaborative innovation center for medical epigenetics, Tianjin Medical University, Tianjin 300070, P. R. CHINA
  2. 2Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Frontier Science Centre of Immunology and Metabolism, Wuhan University, Wuhan 430072, P. R. CHINA
  3. 3Department of Radiation Oncology, Tianjin Medical University General Hospital, Tianjin 300052, P. R. CHINA
  1. ↵*Correspondence for XC, xfchen{at}whu.edu.cn; for SX, xiangsong{at}tmu.edu.cn
  1. ↵# Equal contribution authors

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Posted October 24, 2022.
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Structural basis for the Rad6 activation by the Bre1 N-terminal domain
Meng Shi, Jiaqi Zhao, Mengfei Li, Wei Huang, Xue Bai, Wenxue Zhang, Kai Zhang, Xuefeng Chen, Song Xiang
bioRxiv 2022.10.23.513400; doi: https://doi.org/10.1101/2022.10.23.513400
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Structural basis for the Rad6 activation by the Bre1 N-terminal domain
Meng Shi, Jiaqi Zhao, Mengfei Li, Wei Huang, Xue Bai, Wenxue Zhang, Kai Zhang, Xuefeng Chen, Song Xiang
bioRxiv 2022.10.23.513400; doi: https://doi.org/10.1101/2022.10.23.513400

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