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Mechanotransduction events at the physiological site of touch detection

View ORCID ProfileLuke H. Ziolkowski, View ORCID ProfileElena O. Gracheva, View ORCID ProfileSviatoslav N. Bagriantsev
doi: https://doi.org/10.1101/2022.10.23.513402
Luke H. Ziolkowski
1Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
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Elena O. Gracheva
1Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
2Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
3Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
4Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
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  • For correspondence: elena.gracheva@yale.edu slav.bagriantsev@yale.edu
Sviatoslav N. Bagriantsev
1Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
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  • For correspondence: elena.gracheva@yale.edu slav.bagriantsev@yale.edu
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Abstract

Afferents of peripheral mechanoreceptors innervate the skin of vertebrates, where they detect physical touch via mechanically gated ion channels (mechanotransducers). While the afferent terminal is generally understood to be the primary site of mechanotransduction, the functional properties of mechanically activated (MA) ionic current generated by mechanotransducers at this location remain obscure. Here, we report patch-clamp recordings from the afferent terminal innervating Grandry (Meissner) corpuscles in the bill skin of a tactile specialist duck. We show that mechanical stimulation evokes MA current in the afferent with fast kinetics of activation and inactivation during the dynamic phases of the mechanical stimulus. These responses trigger rapidly adapting firing in the afferent detected at the terminal and in the afferent fiber outside of the corpuscle. Our findings elucidate the initial electrogenic events of touch detection in the mechanoreceptor nerve terminal.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted October 24, 2022.
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Mechanotransduction events at the physiological site of touch detection
Luke H. Ziolkowski, Elena O. Gracheva, Sviatoslav N. Bagriantsev
bioRxiv 2022.10.23.513402; doi: https://doi.org/10.1101/2022.10.23.513402
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Mechanotransduction events at the physiological site of touch detection
Luke H. Ziolkowski, Elena O. Gracheva, Sviatoslav N. Bagriantsev
bioRxiv 2022.10.23.513402; doi: https://doi.org/10.1101/2022.10.23.513402

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