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Peptides that Mimic RS repeats modulate phase separation of SRSF1, revealing a reliance on combined stacking and electrostatic interactions

View ORCID ProfileTalia Fargason, Naiduwadura Ivon Upekala De Silva, Erin King, Zihan Zhang, Trenton Paul, Jamal Shariq, Steve Zaharias, Jun Zhang
doi: https://doi.org/10.1101/2022.10.24.511151
Talia Fargason
1Department of Chemistry, College of Arts and Sciences, University of Alabama at Birmingham, CH266, 901 14th Street South, Birmingham, AL, 35294-1240, USA
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  • ORCID record for Talia Fargason
Naiduwadura Ivon Upekala De Silva
1Department of Chemistry, College of Arts and Sciences, University of Alabama at Birmingham, CH266, 901 14th Street South, Birmingham, AL, 35294-1240, USA
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Erin King
1Department of Chemistry, College of Arts and Sciences, University of Alabama at Birmingham, CH266, 901 14th Street South, Birmingham, AL, 35294-1240, USA
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Zihan Zhang
1Department of Chemistry, College of Arts and Sciences, University of Alabama at Birmingham, CH266, 901 14th Street South, Birmingham, AL, 35294-1240, USA
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Trenton Paul
1Department of Chemistry, College of Arts and Sciences, University of Alabama at Birmingham, CH266, 901 14th Street South, Birmingham, AL, 35294-1240, USA
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Jamal Shariq
1Department of Chemistry, College of Arts and Sciences, University of Alabama at Birmingham, CH266, 901 14th Street South, Birmingham, AL, 35294-1240, USA
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Steve Zaharias
1Department of Chemistry, College of Arts and Sciences, University of Alabama at Birmingham, CH266, 901 14th Street South, Birmingham, AL, 35294-1240, USA
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Jun Zhang
1Department of Chemistry, College of Arts and Sciences, University of Alabama at Birmingham, CH266, 901 14th Street South, Birmingham, AL, 35294-1240, USA
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  • For correspondence: zhanguab@uab.edu
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Posted October 24, 2022.
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Peptides that Mimic RS repeats modulate phase separation of SRSF1, revealing a reliance on combined stacking and electrostatic interactions
Talia Fargason, Naiduwadura Ivon Upekala De Silva, Erin King, Zihan Zhang, Trenton Paul, Jamal Shariq, Steve Zaharias, Jun Zhang
bioRxiv 2022.10.24.511151; doi: https://doi.org/10.1101/2022.10.24.511151
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Peptides that Mimic RS repeats modulate phase separation of SRSF1, revealing a reliance on combined stacking and electrostatic interactions
Talia Fargason, Naiduwadura Ivon Upekala De Silva, Erin King, Zihan Zhang, Trenton Paul, Jamal Shariq, Steve Zaharias, Jun Zhang
bioRxiv 2022.10.24.511151; doi: https://doi.org/10.1101/2022.10.24.511151

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