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Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB

Michael D. Sacco, Lauren R. Hammond, Radwan E. Noor, Dipanwita Bhattacharya, Jesper J. Madsen, Xiujun Zhang, Shane G. Butler, M. Trent Kemp, Aiden C. Jaskolka-Brown, Sebastian J. Khan, Ioannis Gelis, View ORCID ProfilePrahathees J. Eswara, View ORCID ProfileYu Chen
doi: https://doi.org/10.1101/2022.10.25.513704
Michael D. Sacco
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, United States
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Lauren R. Hammond
2Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, 33620, United States
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Radwan E. Noor
3Department of Chemistry, University of South Florida, Tampa, FL, 33620, United States
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Dipanwita Bhattacharya
2Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, 33620, United States
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Jesper J. Madsen
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, United States
4Global and Planetary Health, College of Public Health, University of South Florida, Tampa, FL, 33612, United States
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Xiujun Zhang
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, United States
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Shane G. Butler
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, United States
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M. Trent Kemp
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, United States
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Aiden C. Jaskolka-Brown
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, United States
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Sebastian J. Khan
2Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, 33620, United States
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Ioannis Gelis
3Department of Chemistry, University of South Florida, Tampa, FL, 33620, United States
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Prahathees J. Eswara
2Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, 33620, United States
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  • ORCID record for Prahathees J. Eswara
  • For correspondence: ychen1@usf.edu
Yu Chen
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, United States
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  • ORCID record for Yu Chen
  • For correspondence: ychen1@usf.edu
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Article Information

doi 
https://doi.org/10.1101/2022.10.25.513704
History 
  • October 25, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Michael D. Sacco1,#,
  2. Lauren R. Hammond2,#,
  3. Radwan E. Noor3,
  4. Dipanwita Bhattacharya2,
  5. Jesper J. Madsen1,4,
  6. Xiujun Zhang1,
  7. Shane G. Butler1,
  8. M. Trent Kemp1,
  9. Aiden C. Jaskolka-Brown1,
  10. Sebastian J. Khan2,
  11. Ioannis Gelis3,
  12. Prahathees J. Eswara2,* and
  13. Yu Chen1,*
  1. 1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, United States
  2. 2Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, 33620, United States
  3. 3Department of Chemistry, University of South Florida, Tampa, FL, 33620, United States
  4. 4Global and Planetary Health, College of Public Health, University of South Florida, Tampa, FL, 33612, United States
  1. ↵*Corresponding authors ychen1{at}usf.edu
  1. ↵# These authors contributed equally to this work.

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Posted October 25, 2022.
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Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB
Michael D. Sacco, Lauren R. Hammond, Radwan E. Noor, Dipanwita Bhattacharya, Jesper J. Madsen, Xiujun Zhang, Shane G. Butler, M. Trent Kemp, Aiden C. Jaskolka-Brown, Sebastian J. Khan, Ioannis Gelis, Prahathees J. Eswara, Yu Chen
bioRxiv 2022.10.25.513704; doi: https://doi.org/10.1101/2022.10.25.513704
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Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB
Michael D. Sacco, Lauren R. Hammond, Radwan E. Noor, Dipanwita Bhattacharya, Jesper J. Madsen, Xiujun Zhang, Shane G. Butler, M. Trent Kemp, Aiden C. Jaskolka-Brown, Sebastian J. Khan, Ioannis Gelis, Prahathees J. Eswara, Yu Chen
bioRxiv 2022.10.25.513704; doi: https://doi.org/10.1101/2022.10.25.513704

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