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Tumor-educated Gr1+CD11b+ cells instigate breast cancer metastasis by twisting cancer cells plasticity via OSM/IL6–JAK signaling

Sanam Peyvandi, Manon Bulliard, Annamaria Kauzlaric, Oriana Coquoz, Yu-Ting Huang, Nathalie Duffey, Laetitia Gafner, Girieca Lorusso, Nadine Fournier, View ORCID ProfileQiang Lan, Curzio Rüegg
doi: https://doi.org/10.1101/2022.10.26.513889
Sanam Peyvandi
1Pathology Unit, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland
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Manon Bulliard
1Pathology Unit, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland
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Annamaria Kauzlaric
2Translational Data Science Group, Swiss Institute of Bioinformatics, Lausanne, Switzerland
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Oriana Coquoz
1Pathology Unit, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland
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Yu-Ting Huang
1Pathology Unit, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland
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Nathalie Duffey
1Pathology Unit, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland
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Laetitia Gafner
1Pathology Unit, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland
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Girieca Lorusso
1Pathology Unit, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland
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Nadine Fournier
2Translational Data Science Group, Swiss Institute of Bioinformatics, Lausanne, Switzerland
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Qiang Lan
1Pathology Unit, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland
3Cell and Tissue Dynamics Research Program, Institute of Biotechnology, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland
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  • ORCID record for Qiang Lan
  • For correspondence: curzio.ruegg@unifr.ch qiang.lan@helsinki.fi
Curzio Rüegg
1Pathology Unit, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland
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  • For correspondence: curzio.ruegg@unifr.ch qiang.lan@helsinki.fi
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Article Information

doi 
https://doi.org/10.1101/2022.10.26.513889
History 
  • November 7, 2022.

Article Versions

  • Version 1 (October 27, 2022 - 01:45).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Sanam Peyvandi1,+,*,
  2. Manon Bulliard1,+,
  3. Annamaria Kauzlaric2,
  4. Oriana Coquoz1,
  5. Yu-Ting Huang1,
  6. Nathalie Duffey1,+,
  7. Laetitia Gafner1,
  8. Girieca Lorusso1,
  9. Nadine Fournier2,
  10. Qiang Lan1,3,#,* and
  11. Curzio Rüegg1,#,*
  1. 1Pathology Unit, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland
  2. 2Translational Data Science Group, Swiss Institute of Bioinformatics, Lausanne, Switzerland
  3. 3Cell and Tissue Dynamics Research Program, Institute of Biotechnology, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland
  1. ↵# Lead contacts and co-senior authors: # C.R. (curzio.ruegg{at}unifr.ch; +4126 300 8766), Department of Oncology, Microbiology, Immunology, Faculty of Science and Medicine, University of Fribourg, Chemin du Musée 18, Per 17, CH-1700 Fribourg, Switzerland # Q.L. (qiang.lan{at}helsinki.fi) Cell and Tissue Dynamics Research Program, Institute of Biotechnology, Helsinki Institute of Life Science (HiLIFE), Biocenter 2, P.O. Box 56, FIN-00014, University of Helsinki, Helsinki, Finland
  1. ↵* These authors contributed equally as corresponding authors.

  • ↵+ S.P., Immunobiology Department, University of Lausanne (UNIL), Switzerland; M.B., Swiss Institute for Experimental Cancer Research (ISREC), Ecole Polytechnique Fédérale Lausanne (EPFL) UPCDA SV 2833 (Bâtiment SV) Lausanne, Switzerland; N.D., Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne (UNIL), Switzerland; Y-T.H., Daiichi Sankyo Co., Ltd. Taipei City, Taiwan

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Tumor-educated Gr1+CD11b+ cells instigate breast cancer metastasis by twisting cancer cells plasticity via OSM/IL6–JAK signaling
Sanam Peyvandi, Manon Bulliard, Annamaria Kauzlaric, Oriana Coquoz, Yu-Ting Huang, Nathalie Duffey, Laetitia Gafner, Girieca Lorusso, Nadine Fournier, Qiang Lan, Curzio Rüegg
bioRxiv 2022.10.26.513889; doi: https://doi.org/10.1101/2022.10.26.513889
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Tumor-educated Gr1+CD11b+ cells instigate breast cancer metastasis by twisting cancer cells plasticity via OSM/IL6–JAK signaling
Sanam Peyvandi, Manon Bulliard, Annamaria Kauzlaric, Oriana Coquoz, Yu-Ting Huang, Nathalie Duffey, Laetitia Gafner, Girieca Lorusso, Nadine Fournier, Qiang Lan, Curzio Rüegg
bioRxiv 2022.10.26.513889; doi: https://doi.org/10.1101/2022.10.26.513889

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