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Overcoming the Blood-Brain Barrier for Gene Therapy via Systemic Administration of GSH-Responsive Silica Nanocapsules

Yuyuan Wang, Xiuxiu Wang, Ruosen Xie, Jacobus C. Burger, Yao Tong, View ORCID ProfileShaoqin Gong
doi: https://doi.org/10.1101/2022.10.27.513950
Yuyuan Wang
1Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA
2Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
3Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA
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Xiuxiu Wang
1Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA
2Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
3Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA
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Ruosen Xie
1Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA
2Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
3Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA
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Jacobus C. Burger
2Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
3Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA
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Yao Tong
2Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
3Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA
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Shaoqin Gong
1Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA
2Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
3Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA
4Department of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
5Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA
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  • ORCID record for Shaoqin Gong
  • For correspondence: shaoqingong@wisc.edu
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Article Information

doi 
https://doi.org/10.1101/2022.10.27.513950
History 
  • October 28, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Yuyuan Wang1,2,3,
  2. Xiuxiu Wang1,2,3,
  3. Ruosen Xie1,2,3,
  4. Jacobus C. Burger2,3,
  5. Yao Tong2,3 and
  6. Shaoqin Gong1,2,3,4,5,*
  1. 1Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA
  2. 2Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
  3. 3Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA
  4. 4Department of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
  5. 5Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA
  1. ↵*: Correspondence should be addressed to SG (shaoqingong{at}wisc.edu)
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Posted October 28, 2022.
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Overcoming the Blood-Brain Barrier for Gene Therapy via Systemic Administration of GSH-Responsive Silica Nanocapsules
Yuyuan Wang, Xiuxiu Wang, Ruosen Xie, Jacobus C. Burger, Yao Tong, Shaoqin Gong
bioRxiv 2022.10.27.513950; doi: https://doi.org/10.1101/2022.10.27.513950
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Overcoming the Blood-Brain Barrier for Gene Therapy via Systemic Administration of GSH-Responsive Silica Nanocapsules
Yuyuan Wang, Xiuxiu Wang, Ruosen Xie, Jacobus C. Burger, Yao Tong, Shaoqin Gong
bioRxiv 2022.10.27.513950; doi: https://doi.org/10.1101/2022.10.27.513950

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