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Overcoming the Blood-Brain Barrier for Gene Therapy via Systemic Administration of GSH-Responsive Silica Nanocapsules

Yuyuan Wang, Xiuxiu Wang, Ruosen Xie, Jacobus C. Burger, Yao Tong, View ORCID ProfileShaoqin Gong
doi: https://doi.org/10.1101/2022.10.27.513950
Yuyuan Wang
1Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA
2Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
3Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA
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Xiuxiu Wang
1Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA
2Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
3Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA
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Ruosen Xie
1Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA
2Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
3Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA
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Jacobus C. Burger
2Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
3Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA
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Yao Tong
2Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
3Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA
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Shaoqin Gong
1Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53705, USA
2Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
3Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA
4Department of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA
5Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA
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  • ORCID record for Shaoqin Gong
  • For correspondence: shaoqingong@wisc.edu
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  • Methods, Supplementary Figures S1-S23, Supplementary Tables S1-S4[supplements/513950_file03.pdf]
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Posted October 28, 2022.
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Overcoming the Blood-Brain Barrier for Gene Therapy via Systemic Administration of GSH-Responsive Silica Nanocapsules
Yuyuan Wang, Xiuxiu Wang, Ruosen Xie, Jacobus C. Burger, Yao Tong, Shaoqin Gong
bioRxiv 2022.10.27.513950; doi: https://doi.org/10.1101/2022.10.27.513950
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Overcoming the Blood-Brain Barrier for Gene Therapy via Systemic Administration of GSH-Responsive Silica Nanocapsules
Yuyuan Wang, Xiuxiu Wang, Ruosen Xie, Jacobus C. Burger, Yao Tong, Shaoqin Gong
bioRxiv 2022.10.27.513950; doi: https://doi.org/10.1101/2022.10.27.513950

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