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Human acute microelectrode array recordings with broad cortical access, single-unit resolution and parallel behavioral monitoring

Viktor M. Eisenkolb, Lisa M. Held, Alexander Utzschmid, Xiao-Xiong Lin, View ORCID ProfileSandro M. Krieg, Bernhard Meyer, Jens Gempt, View ORCID ProfileSimon N. Jacob
doi: https://doi.org/10.1101/2022.10.27.514100
Viktor M. Eisenkolb
1Translational Neurotechnology Laboratory, Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
2Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
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Lisa M. Held
1Translational Neurotechnology Laboratory, Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
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Alexander Utzschmid
1Translational Neurotechnology Laboratory, Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
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Xiao-Xiong Lin
1Translational Neurotechnology Laboratory, Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
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Sandro M. Krieg
2Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
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Bernhard Meyer
2Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
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Jens Gempt
2Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
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Simon N. Jacob
1Translational Neurotechnology Laboratory, Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
2Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
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  • For correspondence: simon.jacob@tum.de
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Abstract

Human single-unit studies currently rely on neurosurgical procedures that provide only limited brain coverage and on recording devices that do not integrate easily into established surgical routines. Here, we report reliable and robust acute multi-channel recordings with broad cortical access using planar microelectrode arrays (MEA) implanted intracortically in awake brain surgery. We provide a comprehensive characterization of extracellular neuronal activity acquired intraoperatively in tumor patients with large open craniotomies. MEA implantation was fast, safe and yielded high-quality signals at the microcircuit, local field potential level, and at the cellular, single-unit level. Recording from parietal association cortex, a region previously unexplored in human single-unit studies, we demonstrate applications on these complementary spatial scales and describe travelling waves of oscillatory activity as well as single-neuron and neuronal population responses during numerical cognition including operations with uniquely human number symbols. Intraoperative MEA recordings are practicable and can be scaled up to explore cellular and microcircuit mechanisms of a wide range of human brain functions.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted October 28, 2022.
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Human acute microelectrode array recordings with broad cortical access, single-unit resolution and parallel behavioral monitoring
Viktor M. Eisenkolb, Lisa M. Held, Alexander Utzschmid, Xiao-Xiong Lin, Sandro M. Krieg, Bernhard Meyer, Jens Gempt, Simon N. Jacob
bioRxiv 2022.10.27.514100; doi: https://doi.org/10.1101/2022.10.27.514100
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Human acute microelectrode array recordings with broad cortical access, single-unit resolution and parallel behavioral monitoring
Viktor M. Eisenkolb, Lisa M. Held, Alexander Utzschmid, Xiao-Xiong Lin, Sandro M. Krieg, Bernhard Meyer, Jens Gempt, Simon N. Jacob
bioRxiv 2022.10.27.514100; doi: https://doi.org/10.1101/2022.10.27.514100

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