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Allosteric inhibition of the epidermal growth factor receptor through disruption of transmembrane interactions

View ORCID ProfileJennifer A Rybak, Amita R Sahoo, Soyeon Kim, Robert J Pyron, Savannah B Pitts, Saffet Guleryuz, Adam W Smith, Matthias Buck, View ORCID ProfileFrancisco N Barrera
doi: https://doi.org/10.1101/2022.10.31.514582
Jennifer A Rybak
1Department of Genome Sciences and Technology, University of Tennessee, 1311 Cumberland Avenue, Knoxville, TN 37996, USA
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  • ORCID record for Jennifer A Rybak
Amita R Sahoo
2Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
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Soyeon Kim
3Department of Chemistry, University of Akron, 190 Buchtel Common, Akron, Ohio 44325, USA
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Robert J Pyron
4Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, 1311 Cumberland Avenue, Knoxville, TN 37996, USA
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Savannah B Pitts
4Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, 1311 Cumberland Avenue, Knoxville, TN 37996, USA
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Saffet Guleryuz
5Department of Medicine, University of Tennessee Graduate School of Medicine, 1924 Alcoa Hwy, Knoxville, TN, 37920, USA
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Adam W Smith
3Department of Chemistry, University of Akron, 190 Buchtel Common, Akron, Ohio 44325, USA
6Department of Chemistry and Biochemistry, Texas Tech University, 2500 Broadway St, Lubbock, TX 79409
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Matthias Buck
2Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
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Francisco N Barrera
4Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, 1311 Cumberland Avenue, Knoxville, TN 37996, USA
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  • ORCID record for Francisco N Barrera
  • For correspondence: fbarrera@utk.edu
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Article Information

doi 
https://doi.org/10.1101/2022.10.31.514582
History 
  • November 1, 2022.

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  • You are currently viewing Version 1 of this article (November 1, 2022 - 09:12).
  • View Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Jennifer A Rybak1,
  2. Amita R Sahoo2,
  3. Soyeon Kim3,
  4. Robert J Pyron4,
  5. Savannah B Pitts4,
  6. Saffet Guleryuz5,
  7. Adam W Smith3,6,
  8. Matthias Buck2 and
  9. Francisco N Barrera4,*
  1. 1Department of Genome Sciences and Technology, University of Tennessee, 1311 Cumberland Avenue, Knoxville, TN 37996, USA
  2. 2Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
  3. 3Department of Chemistry, University of Akron, 190 Buchtel Common, Akron, Ohio 44325, USA
  4. 4Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, 1311 Cumberland Avenue, Knoxville, TN 37996, USA
  5. 5Department of Medicine, University of Tennessee Graduate School of Medicine, 1924 Alcoa Hwy, Knoxville, TN, 37920, USA
  6. 6Department of Chemistry and Biochemistry, Texas Tech University, 2500 Broadway St, Lubbock, TX 79409
  1. ↵*Corresponding author; email: fbarrera{at}utk.edu
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Posted November 01, 2022.
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Allosteric inhibition of the epidermal growth factor receptor through disruption of transmembrane interactions
Jennifer A Rybak, Amita R Sahoo, Soyeon Kim, Robert J Pyron, Savannah B Pitts, Saffet Guleryuz, Adam W Smith, Matthias Buck, Francisco N Barrera
bioRxiv 2022.10.31.514582; doi: https://doi.org/10.1101/2022.10.31.514582
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Allosteric inhibition of the epidermal growth factor receptor through disruption of transmembrane interactions
Jennifer A Rybak, Amita R Sahoo, Soyeon Kim, Robert J Pyron, Savannah B Pitts, Saffet Guleryuz, Adam W Smith, Matthias Buck, Francisco N Barrera
bioRxiv 2022.10.31.514582; doi: https://doi.org/10.1101/2022.10.31.514582

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