Allosteric inhibition of the epidermal growth factor receptor through disruption of transmembrane interactions

Jennifer A Rybak; Amita R Sahoo; Soyeon Kim; Robert J Pyron; Savannah B Pitts; Saffet Guleryuz; Adam W Smith; Matthias Buck; Francisco N Barrera

doi:10.1101/2022.10.31.514582

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Allosteric inhibition of the epidermal growth factor receptor through disruption of transmembrane interactions

View ORCID ProfileJennifer A Rybak, Amita R Sahoo, Soyeon Kim, Robert J Pyron, Savannah B Pitts, Saffet Guleryuz, Adam W Smith, Matthias Buck, View ORCID ProfileFrancisco N Barrera

doi: https://doi.org/10.1101/2022.10.31.514582

Jennifer A Rybak

1Department of Genome Sciences and Technology, University of Tennessee, 1311 Cumberland Avenue, Knoxville, TN 37996, USA

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ORCID record for Jennifer A Rybak

Amita R Sahoo

2Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA

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Soyeon Kim

3Department of Chemistry, University of Akron, 190 Buchtel Common, Akron, Ohio 44325, USA

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Robert J Pyron

4Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, 1311 Cumberland Avenue, Knoxville, TN 37996, USA

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Savannah B Pitts

4Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, 1311 Cumberland Avenue, Knoxville, TN 37996, USA

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Saffet Guleryuz

5Department of Medicine, University of Tennessee Graduate School of Medicine, 1924 Alcoa Hwy, Knoxville, TN, 37920, USA

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Adam W Smith

3Department of Chemistry, University of Akron, 190 Buchtel Common, Akron, Ohio 44325, USA

6Department of Chemistry and Biochemistry, Texas Tech University, 2500 Broadway St, Lubbock, TX 79409

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Matthias Buck

2Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA

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Francisco N Barrera

4Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, 1311 Cumberland Avenue, Knoxville, TN 37996, USA

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ORCID record for Francisco N Barrera
For correspondence: fbarrera@utk.edu

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Allosteric inhibition of the epidermal growth factor receptor through disruption of transmembrane interactions

Jennifer A Rybak, Amita R Sahoo, Soyeon Kim, Robert J Pyron, Savannah B Pitts, Saffet Guleryuz, Adam W Smith, Matthias Buck, Francisco N Barrera

bioRxiv 2022.10.31.514582; doi: https://doi.org/10.1101/2022.10.31.514582

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Allosteric inhibition of the epidermal growth factor receptor through disruption of transmembrane interactions

Jennifer A Rybak, Amita R Sahoo, Soyeon Kim, Robert J Pyron, Savannah B Pitts, Saffet Guleryuz, Adam W Smith, Matthias Buck, Francisco N Barrera

bioRxiv 2022.10.31.514582; doi: https://doi.org/10.1101/2022.10.31.514582

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