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A low-cost recombinant glycoconjugate vaccine confers immunogenicity and protection against enterotoxigenic Escherichia coli infections in mice

Asher J. Williams, Katherine F. Warfel, Primit Desai, Jie Li, Jen-Jie Lee, Derek A. Wong, Sarah E. Sobol, Michael C. Jewett, Yung-Fu Chang, View ORCID ProfileMatthew P. DeLisa
doi: https://doi.org/10.1101/2022.10.31.514630
Asher J. Williams
1Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853 USA
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Katherine F. Warfel
2Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Technological Institute E136, Evanston, IL 60208, USA
3Chemistry of Life Processes Institute, Northwestern University, 2170 Campus Drive, Evanston, IL 60208, USA
4Center for Synthetic Biology, Northwestern University, 2145 Sheridan Road, Technological Institute E136, Evanston, IL 60208, USA
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Primit Desai
5Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853
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Jie Li
6Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853 USA
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Jen-Jie Lee
6Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853 USA
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Derek A. Wong
2Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Technological Institute E136, Evanston, IL 60208, USA
3Chemistry of Life Processes Institute, Northwestern University, 2170 Campus Drive, Evanston, IL 60208, USA
4Center for Synthetic Biology, Northwestern University, 2145 Sheridan Road, Technological Institute E136, Evanston, IL 60208, USA
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Sarah E. Sobol
2Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Technological Institute E136, Evanston, IL 60208, USA
3Chemistry of Life Processes Institute, Northwestern University, 2170 Campus Drive, Evanston, IL 60208, USA
4Center for Synthetic Biology, Northwestern University, 2145 Sheridan Road, Technological Institute E136, Evanston, IL 60208, USA
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Michael C. Jewett
2Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Technological Institute E136, Evanston, IL 60208, USA
3Chemistry of Life Processes Institute, Northwestern University, 2170 Campus Drive, Evanston, IL 60208, USA
4Center for Synthetic Biology, Northwestern University, 2145 Sheridan Road, Technological Institute E136, Evanston, IL 60208, USA
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Yung-Fu Chang
6Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853 USA
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Matthew P. DeLisa
1Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853 USA
5Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853
7Cornell Institute of Biotechnology, Cornell University, Ithaca, NY 14853 USA
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  • ORCID record for Matthew P. DeLisa
  • For correspondence: md255@cornell.edu
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Posted November 01, 2022.
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A low-cost recombinant glycoconjugate vaccine confers immunogenicity and protection against enterotoxigenic Escherichia coli infections in mice
Asher J. Williams, Katherine F. Warfel, Primit Desai, Jie Li, Jen-Jie Lee, Derek A. Wong, Sarah E. Sobol, Michael C. Jewett, Yung-Fu Chang, Matthew P. DeLisa
bioRxiv 2022.10.31.514630; doi: https://doi.org/10.1101/2022.10.31.514630
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A low-cost recombinant glycoconjugate vaccine confers immunogenicity and protection against enterotoxigenic Escherichia coli infections in mice
Asher J. Williams, Katherine F. Warfel, Primit Desai, Jie Li, Jen-Jie Lee, Derek A. Wong, Sarah E. Sobol, Michael C. Jewett, Yung-Fu Chang, Matthew P. DeLisa
bioRxiv 2022.10.31.514630; doi: https://doi.org/10.1101/2022.10.31.514630

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