Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Stronger transcriptomic response to feed intake in the duodenum of pig with high feed efficiency from a divergent selection experiment

View ORCID ProfileGuillaume Devailly, View ORCID ProfileKatia Fève, Safia Saci, Julien Sarry, Sophie Valière, Jérôme Lluch, Olivier Bouchez, Laure Ravon, View ORCID ProfileYvon Billon, View ORCID ProfileHélène Gilbert, View ORCID ProfileMartin Beaumont, View ORCID ProfileJulie Demars
doi: https://doi.org/10.1101/2022.11.03.515018
Guillaume Devailly
1GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet Tolosan, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Guillaume Devailly
  • For correspondence: guillaume.devailly@inrae.fr
Katia Fève
1GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet Tolosan, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Katia Fève
Safia Saci
1GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet Tolosan, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julien Sarry
1GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet Tolosan, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sophie Valière
2INRAE, US 1426, GeT-PlaGe, Genotoul, Castanet-Tolosan, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jérôme Lluch
2INRAE, US 1426, GeT-PlaGe, Genotoul, Castanet-Tolosan, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Olivier Bouchez
2INRAE, US 1426, GeT-PlaGe, Genotoul, Castanet-Tolosan, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laure Ravon
3Pig phenotyping and Innovative breeding facility, GenESI, UE1372, INRAE, F-17700 Surgères, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yvon Billon
3Pig phenotyping and Innovative breeding facility, GenESI, UE1372, INRAE, F-17700 Surgères, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yvon Billon
Hélène Gilbert
1GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet Tolosan, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Hélène Gilbert
Martin Beaumont
1GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet Tolosan, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Martin Beaumont
Julie Demars
1GenPhySE, Université de Toulouse, INRAE, ENVT, 31326, Castanet Tolosan, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Julie Demars
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Data/Code
  • Preview PDF
Loading

Abstract

Feed efficiency is a trait of interest in pigs as it contributes to lowering the ecological and economical costs of pig production. A divergent genetic selection experiment from a Large White pig population was performed for 10 generations, leading to pig lines with relative low- (LRFI, more efficient) and high- (HRFI, less efficient) residual feed intake (RFI). The meals of pigs from the LRFI line are shorter and less frequent as compared to the HRFI line. We hypothesised that these differences in feeding behaviour could be related to differential sensing and absorption of nutrients in the intestine.

Here we investigated the duodenum transcriptomic response to short term feed intake in LRFI and HRFI lines (n=24). We identified 1106 differentially expressed genes between the two lines, notably affecting pathways of the transmembrane transport activity and related to mitosis or chromosome separation. The LRFI line showed a greater transcriptomic response to feed intake, with 2222 differentially expressed genes before and after a meal, as compared to 61 differentially expressed genes in the HRFI line. Feed intake affected genes from both anabolic and catabolic pathways in the pig duodenum, such as autophagy and rRNA production. We noted that several nutrient transporter genes were differentially expressed between lines and/or by short term feed intake.

Altogether, our findings highlighted that the genetic selection for feed efficiency in pigs changed the transcriptome profiles of the duodenum, and notably its response to feed intake.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://forgemia.inra.fr/genepi/analyses/rosepigs

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Back to top
PreviousNext
Posted November 04, 2022.
Download PDF

Supplementary Material

Data/Code
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Stronger transcriptomic response to feed intake in the duodenum of pig with high feed efficiency from a divergent selection experiment
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Stronger transcriptomic response to feed intake in the duodenum of pig with high feed efficiency from a divergent selection experiment
Guillaume Devailly, Katia Fève, Safia Saci, Julien Sarry, Sophie Valière, Jérôme Lluch, Olivier Bouchez, Laure Ravon, Yvon Billon, Hélène Gilbert, Martin Beaumont, Julie Demars
bioRxiv 2022.11.03.515018; doi: https://doi.org/10.1101/2022.11.03.515018
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Stronger transcriptomic response to feed intake in the duodenum of pig with high feed efficiency from a divergent selection experiment
Guillaume Devailly, Katia Fève, Safia Saci, Julien Sarry, Sophie Valière, Jérôme Lluch, Olivier Bouchez, Laure Ravon, Yvon Billon, Hélène Gilbert, Martin Beaumont, Julie Demars
bioRxiv 2022.11.03.515018; doi: https://doi.org/10.1101/2022.11.03.515018

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Genomics
Subject Areas
All Articles
  • Animal Behavior and Cognition (4232)
  • Biochemistry (9126)
  • Bioengineering (6774)
  • Bioinformatics (23985)
  • Biophysics (12116)
  • Cancer Biology (9520)
  • Cell Biology (13772)
  • Clinical Trials (138)
  • Developmental Biology (7626)
  • Ecology (11683)
  • Epidemiology (2066)
  • Evolutionary Biology (15502)
  • Genetics (10637)
  • Genomics (14318)
  • Immunology (9476)
  • Microbiology (22828)
  • Molecular Biology (9088)
  • Neuroscience (48947)
  • Paleontology (355)
  • Pathology (1480)
  • Pharmacology and Toxicology (2567)
  • Physiology (3844)
  • Plant Biology (8325)
  • Scientific Communication and Education (1471)
  • Synthetic Biology (2296)
  • Systems Biology (6185)
  • Zoology (1300)