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A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration

Simon Weiler, Vahid Rahmati, Marcel Isstas, Johann Wutke, Andreas Walter Stark, Christian Franke, Christian Geis, Otto W. Witte, Mark Hübener, Jürgen Bolz, Troy W. Margrie, Knut Holthoff, Manuel Teichert
doi: https://doi.org/10.1101/2022.11.04.515161
Simon Weiler
1Sainsbury Wellcome Centre for Neuronal Circuits and Behaviour, University College London, 25 Howland Street, London W1T 4JG, United Kingdom
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Vahid Rahmati
2Jena University Hospital, Department of Neurology, Am Klinikum 1, 07747 Jena, Germany
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Marcel Isstas
3Friedrich Schiller University Jena, Institute of General Zoology and Animal Physiology, Erbertstraße 1, 07743 Jena, Germany
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Johann Wutke
2Jena University Hospital, Department of Neurology, Am Klinikum 1, 07747 Jena, Germany
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Andreas Walter Stark
4Friedrich Schiller University Jena, Institute of Applied Optics and Biophysics, Fröbelstieg 1, 07743 Jena, Germany
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Christian Franke
4Friedrich Schiller University Jena, Institute of Applied Optics and Biophysics, Fröbelstieg 1, 07743 Jena, Germany
5Friedrich Schiller University Jena, Jena Center for Soft Matter, Philosophenweg 7, 07743 Jena, Germany
6Friedrich Schiller University Jena, Abbe Center of Photonics, Albert-Einstein-Straße 6, 07745 Jena, Germany
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Christian Geis
2Jena University Hospital, Department of Neurology, Am Klinikum 1, 07747 Jena, Germany
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Otto W. Witte
2Jena University Hospital, Department of Neurology, Am Klinikum 1, 07747 Jena, Germany
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Mark Hübener
7Max Planck Institute for Biological Intelligence, Am Klopferspitz 18, D-82152 Martinsried, Germany
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Jürgen Bolz
3Friedrich Schiller University Jena, Institute of General Zoology and Animal Physiology, Erbertstraße 1, 07743 Jena, Germany
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Troy W. Margrie
1Sainsbury Wellcome Centre for Neuronal Circuits and Behaviour, University College London, 25 Howland Street, London W1T 4JG, United Kingdom
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Knut Holthoff
2Jena University Hospital, Department of Neurology, Am Klinikum 1, 07747 Jena, Germany
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Manuel Teichert
2Jena University Hospital, Department of Neurology, Am Klinikum 1, 07747 Jena, Germany
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  • For correspondence: manuel.teichert@med.uni-jena.de
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Abstract

Tactile sensation and vision are often both utilized for the exploration of objects that are within reach though it is not known whether or how these two distinct sensory systems might combine such information. Here in mice we find that stimulation of the contralateral whisker array suppresses visually evoked activity in a subarea of primary visual cortex (VISp) whose visual space covers the whisker search space. This is mediated by local fast spiking interneurons that receive a direct cortico-cortical input predominantly from layer 6 of the primary somatosensory barrel cortex (SSp-bfd). These data demonstrate functional convergence within and between two primary sensory cortical areas for multisensory object detection and recognition.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 04, 2022.
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A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration
Simon Weiler, Vahid Rahmati, Marcel Isstas, Johann Wutke, Andreas Walter Stark, Christian Franke, Christian Geis, Otto W. Witte, Mark Hübener, Jürgen Bolz, Troy W. Margrie, Knut Holthoff, Manuel Teichert
bioRxiv 2022.11.04.515161; doi: https://doi.org/10.1101/2022.11.04.515161
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A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration
Simon Weiler, Vahid Rahmati, Marcel Isstas, Johann Wutke, Andreas Walter Stark, Christian Franke, Christian Geis, Otto W. Witte, Mark Hübener, Jürgen Bolz, Troy W. Margrie, Knut Holthoff, Manuel Teichert
bioRxiv 2022.11.04.515161; doi: https://doi.org/10.1101/2022.11.04.515161

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