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Activation-inducible CAR expression enables precise control over engineered CAR T cell function

Simon P. Fraessle, Claudia Tschulik, Manuel Effenberger, Vlad Cletiu, Maria Gerget, Kilian Schober, Dirk H. Busch, Lothar Germeroth, Christian Stemberger, Mateusz P. Poltorak
doi: https://doi.org/10.1101/2022.11.08.515608
Simon P. Fraessle
1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany
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Claudia Tschulik
1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany
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Manuel Effenberger
1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany
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  • For correspondence: manuel.effenberger@bms.com
Vlad Cletiu
1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany
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Maria Gerget
1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany
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Kilian Schober
2Institute for Medical Microbiology Immunology and Hygiene, Technical University of Munich, Munich, Germany
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Dirk H. Busch
2Institute for Medical Microbiology Immunology and Hygiene, Technical University of Munich, Munich, Germany
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Lothar Germeroth
1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany
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Christian Stemberger
1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany
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Mateusz P. Poltorak
1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany
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Article Information

doi 
https://doi.org/10.1101/2022.11.08.515608
History 
  • November 8, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Simon P. Fraessle1,#,
  2. Claudia Tschulik1,#,
  3. Manuel Effenberger1,#,*,
  4. Vlad Cletiu1,
  5. Maria Gerget1,
  6. Kilian Schober2,
  7. Dirk H. Busch2,
  8. Lothar Germeroth1,
  9. Christian Stemberger1 and
  10. Mateusz P. Poltorak1
  1. 1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany
  2. 2Institute for Medical Microbiology Immunology and Hygiene, Technical University of Munich, Munich, Germany
  1. ↵*corresponding author Materials & Correspondence
    Correspondence and material requests should be addressed to Dr. Manuel Effenberger (manuel.effenberger{at}bms.com).
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Posted November 08, 2022.
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Activation-inducible CAR expression enables precise control over engineered CAR T cell function
Simon P. Fraessle, Claudia Tschulik, Manuel Effenberger, Vlad Cletiu, Maria Gerget, Kilian Schober, Dirk H. Busch, Lothar Germeroth, Christian Stemberger, Mateusz P. Poltorak
bioRxiv 2022.11.08.515608; doi: https://doi.org/10.1101/2022.11.08.515608
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Activation-inducible CAR expression enables precise control over engineered CAR T cell function
Simon P. Fraessle, Claudia Tschulik, Manuel Effenberger, Vlad Cletiu, Maria Gerget, Kilian Schober, Dirk H. Busch, Lothar Germeroth, Christian Stemberger, Mateusz P. Poltorak
bioRxiv 2022.11.08.515608; doi: https://doi.org/10.1101/2022.11.08.515608

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