Activation-inducible CAR expression enables precise control over engineered CAR T cell function

Simon P. Fraessle; Claudia Tschulik; Manuel Effenberger; Vlad Cletiu; Maria Gerget; Kilian Schober; Dirk H. Busch; Lothar Germeroth; Christian Stemberger; Mateusz P. Poltorak

doi:10.1101/2022.11.08.515608

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Activation-inducible CAR expression enables precise control over engineered CAR T cell function

Simon P. Fraessle, Claudia Tschulik, Manuel Effenberger, Vlad Cletiu, Maria Gerget, Kilian Schober, Dirk H. Busch, Lothar Germeroth, Christian Stemberger, Mateusz P. Poltorak

doi: https://doi.org/10.1101/2022.11.08.515608

Simon P. Fraessle

1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany

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Claudia Tschulik

1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany

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Manuel Effenberger

1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany

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For correspondence: manuel.effenberger@bms.com

Vlad Cletiu

1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany

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Maria Gerget

1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany

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Kilian Schober

2Institute for Medical Microbiology Immunology and Hygiene, Technical University of Munich, Munich, Germany

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Dirk H. Busch

2Institute for Medical Microbiology Immunology and Hygiene, Technical University of Munich, Munich, Germany

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Lothar Germeroth

1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany

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Christian Stemberger

1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany

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Mateusz P. Poltorak

1Juno Therapeutics GmbH, a Bristol-Myers Squibb Company, Grillparzerstr. 10, 81675 Munich, Germany

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Activation-inducible CAR expression enables precise control over engineered CAR T cell function

Simon P. Fraessle, Claudia Tschulik, Manuel Effenberger, Vlad Cletiu, Maria Gerget, Kilian Schober, Dirk H. Busch, Lothar Germeroth, Christian Stemberger, Mateusz P. Poltorak

bioRxiv 2022.11.08.515608; doi: https://doi.org/10.1101/2022.11.08.515608

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Activation-inducible CAR expression enables precise control over engineered CAR T cell function

Simon P. Fraessle, Claudia Tschulik, Manuel Effenberger, Vlad Cletiu, Maria Gerget, Kilian Schober, Dirk H. Busch, Lothar Germeroth, Christian Stemberger, Mateusz P. Poltorak

bioRxiv 2022.11.08.515608; doi: https://doi.org/10.1101/2022.11.08.515608

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