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In-depth specificity profiling of Pro-Pro endopeptidases (PPEPs) using combinatorial synthetic peptide libraries

View ORCID ProfileBart Claushuis, View ORCID ProfileRobert A. Cordfunke, Arnoud H. de Ru, Annemarie Otte, View ORCID ProfileHans C. van Leeuwen, View ORCID ProfileOleg I. Klychnikov, View ORCID ProfilePeter A. van Veelen, View ORCID ProfileJeroen Corver, View ORCID ProfileJan W. Drijfhout, View ORCID ProfilePaul J. Hensbergen
doi: https://doi.org/10.1101/2022.11.15.516584
Bart Claushuis
1Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands
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  • ORCID record for Bart Claushuis
Robert A. Cordfunke
2Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands
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  • ORCID record for Robert A. Cordfunke
Arnoud H. de Ru
1Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands
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Annemarie Otte
1Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands
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Hans C. van Leeuwen
3Department of CBRN Protection, Netherlands Organization for Applied Scientific Research TNO, Rijswijk, The Netherlands
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  • ORCID record for Hans C. van Leeuwen
Oleg I. Klychnikov
4Department of Biochemistry, Moscow State University, Moscow, Russian Federation
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  • ORCID record for Oleg I. Klychnikov
Peter A. van Veelen
1Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands
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Jeroen Corver
5Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
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Jan W. Drijfhout
2Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands
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  • ORCID record for Jan W. Drijfhout
Paul J. Hensbergen
1Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands
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  • ORCID record for Paul J. Hensbergen
  • For correspondence: P.J.Hensbergen@lumc.nl
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Article Information

doi 
https://doi.org/10.1101/2022.11.15.516584
History 
  • November 15, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Bart Claushuis1,
  2. Robert A. Cordfunke2,
  3. Arnoud H. de Ru1,
  4. Annemarie Otte1,
  5. Hans C. van Leeuwen3,
  6. Oleg I. Klychnikov4,
  7. Peter A. van Veelen1,
  8. Jeroen Corver5,
  9. Jan W. Drijfhout2 and
  10. Paul J. Hensbergen1,*
  1. 1Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands
  2. 2Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands
  3. 3Department of CBRN Protection, Netherlands Organization for Applied Scientific Research TNO, Rijswijk, The Netherlands
  4. 4Department of Biochemistry, Moscow State University, Moscow, Russian Federation
  5. 5Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
  1. ↵*Corresponding author:: P.J. Hensbergen, Center for Proteomics and Metabolomics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. Tel.: +31-71-5266394, Fax: +31-71-5266907, E-mail: P.J.Hensbergen{at}lumc.nl
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In-depth specificity profiling of Pro-Pro endopeptidases (PPEPs) using combinatorial synthetic peptide libraries
Bart Claushuis, Robert A. Cordfunke, Arnoud H. de Ru, Annemarie Otte, Hans C. van Leeuwen, Oleg I. Klychnikov, Peter A. van Veelen, Jeroen Corver, Jan W. Drijfhout, Paul J. Hensbergen
bioRxiv 2022.11.15.516584; doi: https://doi.org/10.1101/2022.11.15.516584
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In-depth specificity profiling of Pro-Pro endopeptidases (PPEPs) using combinatorial synthetic peptide libraries
Bart Claushuis, Robert A. Cordfunke, Arnoud H. de Ru, Annemarie Otte, Hans C. van Leeuwen, Oleg I. Klychnikov, Peter A. van Veelen, Jeroen Corver, Jan W. Drijfhout, Paul J. Hensbergen
bioRxiv 2022.11.15.516584; doi: https://doi.org/10.1101/2022.11.15.516584

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