In-depth specificity profiling of Pro-Pro endopeptidases (PPEPs) using combinatorial synthetic peptide libraries

Bart Claushuis; Robert A. Cordfunke; Arnoud H. de Ru; Annemarie Otte; Hans C. van Leeuwen; Oleg I. Klychnikov; Peter A. van Veelen; Jeroen Corver; Jan W. Drijfhout; Paul J. Hensbergen

doi:10.1101/2022.11.15.516584

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In-depth specificity profiling of Pro-Pro endopeptidases (PPEPs) using combinatorial synthetic peptide libraries

View ORCID ProfileBart Claushuis, View ORCID ProfileRobert A. Cordfunke, Arnoud H. de Ru, Annemarie Otte, View ORCID ProfileHans C. van Leeuwen, View ORCID ProfileOleg I. Klychnikov, View ORCID ProfilePeter A. van Veelen, View ORCID ProfileJeroen Corver, View ORCID ProfileJan W. Drijfhout, View ORCID ProfilePaul J. Hensbergen

doi: https://doi.org/10.1101/2022.11.15.516584

Bart Claushuis

1Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands

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Robert A. Cordfunke

2Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands

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Arnoud H. de Ru

1Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands

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Annemarie Otte

1Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands

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Hans C. van Leeuwen

3Department of CBRN Protection, Netherlands Organization for Applied Scientific Research TNO, Rijswijk, The Netherlands

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Oleg I. Klychnikov

4Department of Biochemistry, Moscow State University, Moscow, Russian Federation

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Peter A. van Veelen

1Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands

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Jeroen Corver

5Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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Jan W. Drijfhout

2Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands

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Paul J. Hensbergen

1Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands

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For correspondence: P.J.Hensbergen@lumc.nl

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In-depth specificity profiling of Pro-Pro endopeptidases (PPEPs) using combinatorial synthetic peptide libraries

Bart Claushuis, Robert A. Cordfunke, Arnoud H. de Ru, Annemarie Otte, Hans C. van Leeuwen, Oleg I. Klychnikov, Peter A. van Veelen, Jeroen Corver, Jan W. Drijfhout, Paul J. Hensbergen

bioRxiv 2022.11.15.516584; doi: https://doi.org/10.1101/2022.11.15.516584

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In-depth specificity profiling of Pro-Pro endopeptidases (PPEPs) using combinatorial synthetic peptide libraries

Bart Claushuis, Robert A. Cordfunke, Arnoud H. de Ru, Annemarie Otte, Hans C. van Leeuwen, Oleg I. Klychnikov, Peter A. van Veelen, Jeroen Corver, Jan W. Drijfhout, Paul J. Hensbergen

bioRxiv 2022.11.15.516584; doi: https://doi.org/10.1101/2022.11.15.516584

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