Structural dynamics of E6AP E3 ligase HECT domain and involvement of flexible hinge loop in ubiquitin chain synthesis mechanism

Kazusa Takeda; Ikumi Muro; Fuminori Kobayashi; Holger Flechsig; Noriyuki Kodera; Toshio Ando; Hiroki Konno

doi:10.1101/2022.11.18.516873

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Structural dynamics of E6AP E3 ligase HECT domain and involvement of flexible hinge loop in ubiquitin chain synthesis mechanism

Kazusa Takeda, Ikumi Muro, Fuminori Kobayashi, Holger Flechsig, Noriyuki Kodera, Toshio Ando, Hiroki Konno

doi: https://doi.org/10.1101/2022.11.18.516873

Kazusa Takeda

1Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan

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Ikumi Muro

1Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan

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Fuminori Kobayashi

1Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan

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Holger Flechsig

2WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan

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Noriyuki Kodera

2WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan

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Toshio Ando

2WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan

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Hiroki Konno

2WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan

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For correspondence: hkonno@se.kanazawa-u.ac.jp

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Structural dynamics of E6AP E3 ligase HECT domain and involvement of flexible hinge loop in ubiquitin chain synthesis mechanism

Kazusa Takeda, Ikumi Muro, Fuminori Kobayashi, Holger Flechsig, Noriyuki Kodera, Toshio Ando, Hiroki Konno

bioRxiv 2022.11.18.516873; doi: https://doi.org/10.1101/2022.11.18.516873

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Structural dynamics of E6AP E3 ligase HECT domain and involvement of flexible hinge loop in ubiquitin chain synthesis mechanism

Kazusa Takeda, Ikumi Muro, Fuminori Kobayashi, Holger Flechsig, Noriyuki Kodera, Toshio Ando, Hiroki Konno

bioRxiv 2022.11.18.516873; doi: https://doi.org/10.1101/2022.11.18.516873

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