Modulation of TRPV4 Protects against Degeneration Induced by Sustained Loading and Promotes Matrix Synthesis in the Intervertebral Disc

Garrett W.D. Easson; Alireza Savadipour; Akila Anandarajah; Leanne E. Iannucci; Spencer P. Lake; Farshid Guilak; Simon Y. Tang

doi:10.1101/2022.11.18.516994

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Modulation of TRPV4 Protects against Degeneration Induced by Sustained Loading and Promotes Matrix Synthesis in the Intervertebral Disc

View ORCID ProfileGarrett W.D. Easson, Alireza Savadipour, Akila Anandarajah, View ORCID ProfileLeanne E. Iannucci, Spencer P. Lake, View ORCID ProfileFarshid Guilak, View ORCID ProfileSimon Y. Tang

doi: https://doi.org/10.1101/2022.11.18.516994

Garrett W.D. Easson

1Department of Mechanical Engineering, Washington University in St. Louis, St. Louis, MO, USA

2Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA

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ORCID record for Garrett W.D. Easson

Alireza Savadipour

1Department of Mechanical Engineering, Washington University in St. Louis, St. Louis, MO, USA

2Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA

3Shriner’s Hospital for Children – St. Louis, St. Louis, MO, USA

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Akila Anandarajah

2Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA

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Leanne E. Iannucci

4Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA

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ORCID record for Leanne E. Iannucci

Spencer P. Lake

1Department of Mechanical Engineering, Washington University in St. Louis, St. Louis, MO, USA

4Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA

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Farshid Guilak

1Department of Mechanical Engineering, Washington University in St. Louis, St. Louis, MO, USA

2Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA

3Shriner’s Hospital for Children – St. Louis, St. Louis, MO, USA

4Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA

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Simon Y. Tang

1Department of Mechanical Engineering, Washington University in St. Louis, St. Louis, MO, USA

2Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA

4Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA

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ORCID record for Simon Y. Tang
For correspondence: simon.tang@wustl.edu

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Modulation of TRPV4 Protects against Degeneration Induced by Sustained Loading and Promotes Matrix Synthesis in the Intervertebral Disc

Garrett W.D. Easson, Alireza Savadipour, Akila Anandarajah, Leanne E. Iannucci, Spencer P. Lake, Farshid Guilak, Simon Y. Tang

bioRxiv 2022.11.18.516994; doi: https://doi.org/10.1101/2022.11.18.516994

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Modulation of TRPV4 Protects against Degeneration Induced by Sustained Loading and Promotes Matrix Synthesis in the Intervertebral Disc

Garrett W.D. Easson, Alireza Savadipour, Akila Anandarajah, Leanne E. Iannucci, Spencer P. Lake, Farshid Guilak, Simon Y. Tang

bioRxiv 2022.11.18.516994; doi: https://doi.org/10.1101/2022.11.18.516994

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