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Acyl-CoA dehydrogenase substrate promiscuity limits the potential for development of substrate reduction therapy in disorders of valine and isoleucine metabolism
View ORCID ProfileSander M. Houten, Tetyana Dodatko, William Dwyer, Hongjie Chen, Brandon Stauffer, Robert J. DeVita, View ORCID ProfileFrédéric M. Vaz, Chunli Yu, View ORCID ProfileJoão Leandro
doi: https://doi.org/10.1101/2022.11.22.517273
Sander M. Houten
1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Tetyana Dodatko
1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
William Dwyer
1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Hongjie Chen
1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Mount Sinai Genomics, Inc, Stamford, CT 06902, USA
Brandon Stauffer
1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Mount Sinai Genomics, Inc, Stamford, CT 06902, USA
Robert J. DeVita
3Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Frédéric M. Vaz
5Amsterdam UMC location University of Amsterdam, Department of Clinical Chemistry and Pediatrics, Laboratory Genetic Metabolic Diseases, Emma Children’s Hospital, Meibergdreef 9, Amsterdam, The Netherlands
6Amsterdam Gastroenterology Endocrinology Metabolism, Inborn errors of metabolism, Amsterdam, The Netherlands
7Core Facility Metabolomics, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands
Chunli Yu
1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Mount Sinai Genomics, Inc, Stamford, CT 06902, USA
João Leandro
1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Posted November 22, 2022.
Acyl-CoA dehydrogenase substrate promiscuity limits the potential for development of substrate reduction therapy in disorders of valine and isoleucine metabolism
Sander M. Houten, Tetyana Dodatko, William Dwyer, Hongjie Chen, Brandon Stauffer, Robert J. DeVita, Frédéric M. Vaz, Chunli Yu, João Leandro
bioRxiv 2022.11.22.517273; doi: https://doi.org/10.1101/2022.11.22.517273
Acyl-CoA dehydrogenase substrate promiscuity limits the potential for development of substrate reduction therapy in disorders of valine and isoleucine metabolism
Sander M. Houten, Tetyana Dodatko, William Dwyer, Hongjie Chen, Brandon Stauffer, Robert J. DeVita, Frédéric M. Vaz, Chunli Yu, João Leandro
bioRxiv 2022.11.22.517273; doi: https://doi.org/10.1101/2022.11.22.517273
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