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Evolution of drug resistance drives progressive destabilizations in functionally conserved molecular dynamics of the flap region of the HIV-1 protease
Madhusudan Rajendran, Maureen C. Ferran, Leora Mouli, Eric Everingham, View ORCID ProfileGregory A. Babbitt, Miranda L. Lynch
doi: https://doi.org/10.1101/2022.11.22.517502
Madhusudan Rajendran
1Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester NY, USA 14623
Maureen C. Ferran
1Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester NY, USA 14623
Leora Mouli
1Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester NY, USA 14623
Eric Everingham
1Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester NY, USA 14623
Gregory A. Babbitt
1Thomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester NY, USA 14623
Miranda L. Lynch
2Hauptman-Woodward Medical Research Institute, Buffalo, NY 14203
Posted November 24, 2022.
Evolution of drug resistance drives progressive destabilizations in functionally conserved molecular dynamics of the flap region of the HIV-1 protease
Madhusudan Rajendran, Maureen C. Ferran, Leora Mouli, Eric Everingham, Gregory A. Babbitt, Miranda L. Lynch
bioRxiv 2022.11.22.517502; doi: https://doi.org/10.1101/2022.11.22.517502
Evolution of drug resistance drives progressive destabilizations in functionally conserved molecular dynamics of the flap region of the HIV-1 protease
Madhusudan Rajendran, Maureen C. Ferran, Leora Mouli, Eric Everingham, Gregory A. Babbitt, Miranda L. Lynch
bioRxiv 2022.11.22.517502; doi: https://doi.org/10.1101/2022.11.22.517502
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