IFNγ drives neuroinflammation and demyelination in a mouse model of multiple system atrophy

Nicole J. Gallups; Gabrielle M. Childers; Jhodi M. Webster; Asta Zane; Ya-Ting Yang; Nikhita Mudium; Fredric P. Manfredsson; Jeffrey H. Kordower; Ashley S. Harms

doi:10.1101/2022.11.22.517543

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IFNγ drives neuroinflammation and demyelination in a mouse model of multiple system atrophy

View ORCID ProfileNicole J. Gallups, Gabrielle M. Childers, Jhodi M. Webster, Asta Zane, Ya-Ting Yang, Nikhita Mudium, View ORCID ProfileFredric P. Manfredsson, Jeffrey H. Kordower, Ashley S. Harms

doi: https://doi.org/10.1101/2022.11.22.517543

Nicole J. Gallups

1University of Alabama at Birmingham, Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL

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ORCID record for Nicole J. Gallups

Gabrielle M. Childers

1University of Alabama at Birmingham, Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL

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Jhodi M. Webster

1University of Alabama at Birmingham, Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL

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Asta Zane

1University of Alabama at Birmingham, Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL

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Ya-Ting Yang

1University of Alabama at Birmingham, Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL

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Nikhita Mudium

1University of Alabama at Birmingham, Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL

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Fredric P. Manfredsson

2ASU-Banner Neurodegenerative Disease Research Center, Biodesign Institute, Arizona State University, Tempe, AZ

3Barrow Neurological Institute, Department of Translational Neuroscience, Phoenix, AZ

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ORCID record for Fredric P. Manfredsson

Jeffrey H. Kordower

2ASU-Banner Neurodegenerative Disease Research Center, Biodesign Institute, Arizona State University, Tempe, AZ

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Ashley S. Harms

1University of Alabama at Birmingham, Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, Birmingham, AL

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For correspondence: anharms@uab.edu

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Posted November 23, 2022.

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IFNγ drives neuroinflammation and demyelination in a mouse model of multiple system atrophy

Nicole J. Gallups, Gabrielle M. Childers, Jhodi M. Webster, Asta Zane, Ya-Ting Yang, Nikhita Mudium, Fredric P. Manfredsson, Jeffrey H. Kordower, Ashley S. Harms

bioRxiv 2022.11.22.517543; doi: https://doi.org/10.1101/2022.11.22.517543

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IFNγ drives neuroinflammation and demyelination in a mouse model of multiple system atrophy

Nicole J. Gallups, Gabrielle M. Childers, Jhodi M. Webster, Asta Zane, Ya-Ting Yang, Nikhita Mudium, Fredric P. Manfredsson, Jeffrey H. Kordower, Ashley S. Harms

bioRxiv 2022.11.22.517543; doi: https://doi.org/10.1101/2022.11.22.517543

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