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Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability
Marisol Sampedro-Castañeda, Lucas L. Baltussen, Andre T. Lopes, Yichen Qiu, Liina Sirvio, Simeon R. Mihaylov, Suzanne Claxton, Jill C. Richardson, Gabriele Lignani, Sila Ultanir
doi: https://doi.org/10.1101/2022.11.24.517538
Marisol Sampedro-Castañeda
1Kinases and Brain Development Lab, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom
5These authors contributed equally
Lucas L. Baltussen
1Kinases and Brain Development Lab, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom
4Current address: Laboratory of Synapse Biology (VIB-KU Leuven), Department of Neurosciences, ON5 Herestraat 49, 3000 Leuven, Belgium
5These authors contributed equally
Andre T. Lopes
1Kinases and Brain Development Lab, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom
Yichen Qiu
2Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, 808 Queen Square House, London WC1N 3BG, United Kingdom
Liina Sirvio
1Kinases and Brain Development Lab, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom
Simeon R. Mihaylov
1Kinases and Brain Development Lab, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom
Suzanne Claxton
1Kinases and Brain Development Lab, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom
Jill C. Richardson
3UK Neuroscience Group, MSD R&D Innovation Centre, 120 Moorgate, London, EC2M 6UR, United Kingdom
Gabriele Lignani
2Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, 808 Queen Square House, London WC1N 3BG, United Kingdom
Sila Ultanir
1Kinases and Brain Development Lab, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom
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Posted February 08, 2023.
Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability
Marisol Sampedro-Castañeda, Lucas L. Baltussen, Andre T. Lopes, Yichen Qiu, Liina Sirvio, Simeon R. Mihaylov, Suzanne Claxton, Jill C. Richardson, Gabriele Lignani, Sila Ultanir
bioRxiv 2022.11.24.517538; doi: https://doi.org/10.1101/2022.11.24.517538
Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability
Marisol Sampedro-Castañeda, Lucas L. Baltussen, Andre T. Lopes, Yichen Qiu, Liina Sirvio, Simeon R. Mihaylov, Suzanne Claxton, Jill C. Richardson, Gabriele Lignani, Sila Ultanir
bioRxiv 2022.11.24.517538; doi: https://doi.org/10.1101/2022.11.24.517538
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