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JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease

Chiara Scopa, Samantha M. Barnada, Maria E. Cicardi, Mo Singer, Davide Trotti, Marco Trizzino
doi: https://doi.org/10.1101/2022.11.24.517794
Chiara Scopa
1Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA
2Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA
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  • For correspondence: m.trizzino@imperial.ac.uk chiara.scopa@jefferson.edu
Samantha M. Barnada
1Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA
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Maria E. Cicardi
2Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA
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Mo Singer
2Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA
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Davide Trotti
2Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA
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Marco Trizzino
1Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA
3Department of Life Sciences, Imperial College London, London, UK
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  • For correspondence: m.trizzino@imperial.ac.uk chiara.scopa@jefferson.edu
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Article Information

doi 
https://doi.org/10.1101/2022.11.24.517794
History 
  • November 24, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Chiara Scopa1,2,*,
  2. Samantha M. Barnada1,
  3. Maria E. Cicardi2,
  4. Mo Singer2,
  5. Davide Trotti2,# and
  6. Marco Trizzino1,3,*,#
  1. 1Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA
  2. 2Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA
  3. 3Department of Life Sciences, Imperial College London, London, UK
  1. ↵*Corresponding authors: Marco Trizzino (m.trizzino{at}imperial.ac.uk) and Chiara Scopa (chiara.scopa{at}jefferson.edu)
  1. ↵# Co-lead authors (equal contribution)

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Posted November 24, 2022.
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JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease
Chiara Scopa, Samantha M. Barnada, Maria E. Cicardi, Mo Singer, Davide Trotti, Marco Trizzino
bioRxiv 2022.11.24.517794; doi: https://doi.org/10.1101/2022.11.24.517794
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JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease
Chiara Scopa, Samantha M. Barnada, Maria E. Cicardi, Mo Singer, Davide Trotti, Marco Trizzino
bioRxiv 2022.11.24.517794; doi: https://doi.org/10.1101/2022.11.24.517794

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