JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease

Chiara Scopa; Samantha M. Barnada; Maria E. Cicardi; Mo Singer; Davide Trotti; Marco Trizzino

doi:10.1101/2022.11.24.517794

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JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease

Chiara Scopa, Samantha M. Barnada, Maria E. Cicardi, Mo Singer, Davide Trotti, Marco Trizzino

doi: https://doi.org/10.1101/2022.11.24.517794

Chiara Scopa

1Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA

2Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA

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For correspondence: m.trizzino@imperial.ac.uk chiara.scopa@jefferson.edu

Samantha M. Barnada

1Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA

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Maria E. Cicardi

2Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA

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Mo Singer

2Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA

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Davide Trotti

2Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA

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Marco Trizzino

1Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA

3Department of Life Sciences, Imperial College London, London, UK

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For correspondence: m.trizzino@imperial.ac.uk chiara.scopa@jefferson.edu

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JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease

Chiara Scopa, Samantha M. Barnada, Maria E. Cicardi, Mo Singer, Davide Trotti, Marco Trizzino

bioRxiv 2022.11.24.517794; doi: https://doi.org/10.1101/2022.11.24.517794

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JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease

Chiara Scopa, Samantha M. Barnada, Maria E. Cicardi, Mo Singer, Davide Trotti, Marco Trizzino

bioRxiv 2022.11.24.517794; doi: https://doi.org/10.1101/2022.11.24.517794

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